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Newly recognized: a drug and inflammatory bowel disease () risk

IBD  diabetes  from twitter_favs
2 days ago by cathmnet
Is the "obesity crisis" just a disguise for a deeper problem? - YouTube
Dr Peter Attia, a surgeon, talks about how obesity isn't simple, how we need to understand that the science is not absolute and how much more research needs to be done, and how doctors need compassion more than passing judgement.

His wake-up call was his own T2DM diagnosis, which came despite him eating and exercising "properly."
fat  medicine  video  psychology  bias  diabetes 
10 days ago by moose
Metformin - Wikipedia
Metformin decreases high blood sugar, primarily by suppressing liver glucose production (hepatic gluconeogenesis).[76] The average patient with type 2 diabetes has three times the normal rate of gluconeogenesis; metformin treatment reduces this by over one-third.[91] The molecular mechanism of metformin is incompletely understood. Multiple potential mechanisms of action have been proposed, including; inhibition of the mitochondrial respiratory chain (complex I), activation of AMP-activated protein kinase (AMPK), inhibition of glucagon-induced elevation of cyclic adenosine monophosphate (cAMP) with reduced activation of protein kinase A (PKA), inhibition of mitochondrial glycerophosphate dehydrogenase, and an effect on gut microbiota.[92][93][94]

Activation of AMPK was required for metformin's inhibitory effect on liver glucose production.[95] AMPK is an enzyme that plays an important role in insulin signaling, whole body energy balance and the metabolism of glucose and fats.[96] AMPK Activation was required for an increase in the expression of small heterodimer partner, which in turn inhibited the expression of the hepatic gluconeogenic genes phosphoenolpyruvate carboxykinase and glucose 6-phosphatase.[97] Metformin is frequently used in research along with AICA ribonucleotide as an AMPK agonist. Mouse models in which the genes for AMPKα1 and α2 catalytic subunits (Prkaa1/2) or LKB1, an upstream kinase of AMPK, had been knocked out in hepatocytes, have raised doubts over the role of AMPK, since the effect of metformin was not abolished by loss of AMPK function.[92] The mechanism by which biguanides increase the activity of AMPK remains uncertain; however, metformin increases the concentration of cytosolic adenosine monophosphate (AMP) (as opposed to a change in total AMP or total AMP/adenosine triphosphate).[98] Increased cellular AMP has been proposed to explain the inhibition of glucagon-induced increase in cAMP and activation of PKA.[92] Metformin and other biguanides may antagonize the action of glucagon, thus reducing fasting glucose levels.[99] Metformin also induces a profound shift in the faecal microbial community profile in diabetic mice and this may contribute to its mode of action possibly through an effect on glucagon-like peptide-1 secretion.[93]
metformin  ampk  diabetes 
12 days ago by aheilbut
PhoneBoy's Microblog
Had to measure twice to verify because it was so unbelievable.
diabetes  bgnow  from twitter
16 days ago by phoneboy

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