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Association of Lifestyle and Genetic Risk With Incidence of Dementia | Dementia and Cognitive Impairment | JAMA | JAMA Network
> Of the participants with high genetic risk, 1.23% (95% CI, 1.13%-1.35%) developed dementia compared with 0.63% (95% CI, 0.56%-0.71%) of the participants with low genetic risk (adjusted hazard ratio, 1.91 [95% CI, 1.64-2.23]). Of the participants with a high genetic risk and unfavorable lifestyle, 1.78% (95% CI, 1.38%-2.28%) developed dementia compared with 0.56% (95% CI, 0.48%-0.66%) of participants with low genetic risk and favorable lifestyle (hazard ratio, 2.83 [95% CI, 2.09-3.83]). There was no significant interaction between genetic risk and lifestyle factors (P = .99). Among participants with high genetic risk, 1.13% (95% CI, 1.01%-1.26%) of those with a favorable lifestyle developed dementia compared with 1.78% (95% CI, 1.38%-2.28%) with an unfavorable lifestyle (hazard ratio, 0.68 [95% CI, 0.51-0.90]).
dementia  lifestyle  genetics 
4 days ago by porejide
Prostate Cancer Therapy Makes Dementia More Likely | ALZFORUM
> In the largest U.S. study to date on androgen-deprivation therapy and dementia, researchers led by Ravishankar Jayadevappa, University of Pennsylvania, Philadelphia, found that among older men with prostate cancer, those who received this treatment were about 20 percent more likely to develop Alzheimer’s disease or dementia within eight years of their cancer diagnosis than the untreated men. In a July 3 JAMA Network Open paper, the authors report a dose response whereby those who received more ADT had a higher chance of developing these long-term cognitive outcomes
androgen  dementia  prostate 
15 days ago by porejide
I am working to get a dedicated - they provide specialist support for people…
Wolverhampton  dementia  AdmiralNurse  from twitter_favs
16 days ago by tolkien
The Evidence Is Strong: Air Pollution Seems to Cause Dementia | WIRED
This story originally appeared on Mother Jones and is part of the Climate Desk collaboration.

A few years ago I stood in a cramped trailer beside the busy 110 freeway in Los Angeles as researchers at the University of Southern California gathered soot thrown off by vehicles pounding by just a few yards from their instruments, which rattled whenever a heavy truck passed. I was there to learn about how scientists were beginning to link air pollution—from power plants, motor vehicles, forest fires, you name it—to one of the least understood and most frightening of illnesses: dementia.

At that time, as I reported in Mother Jones, the research implicating air pollution as one factor that can contribute to dementia was alarming, consistent, and, ultimately, “suggestive.” Since then scientists have published a wave of studies that reveal that air pollution is much worse for us than we had previously imagined. The evidence is so compelling, in fact, that many leading researchers now believe it’s conclusive. “I have no hesitation whatsoever to say that air pollution causes dementia,” says Caleb Finch, gerontologist and the leader of USC’s Air Pollution and Brain Disease research network, which has completed many of these new studies. In terms of its effects on our health and welfare, Finch says, “air pollution is just as bad as cigarette smoke.” This evidence arrives alongside the alarming news that air quality is actually worsening for many cities in the United States, while the Trump administration continues its effort to delay or roll back environmental safeguards.

What makes Finch—and the half dozen other researchers I talked to—so sure? Of all the new research, three studies in particular paint a stark picture of the extent to which the quality of our air can determine whether we will age with our minds intact. In one from 2018, researchers followed 130,000 older adults living in London for several years. Those exposed to higher levels of air pollutants, particularly nitrogen dioxide and fine particulate matter released by fossil fuel combustion, were significantly more likely to develop Alzheimer’s disease—the most common kind of dementia—than their otherwise demographically matched peers. In total, Londoners exposed to the highest levels of air pollution were about one and a half times more likely to develop Alzheimer’s across the study period than their neighbors exposed to the lowest levels—a replication of previous findings from Taiwan, where air pollution levels are much higher.

A 2017 study published in The Lancet followed all adults living in Ontario (roughly 6.5 million people) for over a decade and found that those who lived closer to major high-traffic roads were significantly more likely to develop Alzheimer’s disease across the study period, regardless of their health at baseline or socioeconomic status. Both of these studies estimated that around 6 to 7 percent of all dementia cases in their samples could be attributed to air pollution exposures.
dementia  Environment  HealthCare 
16 days ago by cnk
Document Moved
An estimated 5.7 million people in the U.S. have Alzheimer’s disease—the most common type of dementia—and that number is expected to more than double by 2050. Early diagnosis is crucial for patients to benefit from the few therapies available. via Pocket
IFTTT  Pocket  alzheimers  brain  dementia 
18 days ago by eemorningwood
Oregon Lawmakers Consider Expansion Of “Death With Dignity” Law | KLCC
> Yelle supports a pair of bills in Salem that would loosen the criteria for who can use the Death With Dignity Act. Specifically, the measures would remove a key provision of the law: The part that requires a doctor to diagnose the patient as having less than six months to live. The bills would remove the time limit entirely, and only require that the disease will, at some point in the future, be the cause of the patient’s death.
dementia  MAID 
28 days ago by porejide
The Restaurant That Makes Mistakes review – TV to prompt waves of feelings
And all of them speak of the restoration to their self-esteem, soundly clobbered by the loss of jobs and careers, which is an experience common to 80% of all people with dementia diagnosed before retirement age. “Having a purpose,” says Peter, after coming close to tears at sitting down at a computer and sending an email for the first time since he stopped working, “is a great thing.”

It does, however, beg the question of why it is to television that we must so often look for these forms of mass education and destigmatisation. I never know whether to laugh and cheer at the power it has to make a difference, or weep that we don’t seem to be able to get there any other way. Out of the goodness of our own hearts or the operation of our own common sense, perhaps. Or following the lead of a compassionate government that sees it as part of its remit to care for the vulnerable and make understanding different circumstances and lives part of our national fabric.
television  health  mentalhealth  dementia 
28 days ago by terry
The to overcome disease and other forms of requires diverse ideas, skills, and resou…
dementia  Alzheimers  science  from twitter_favs
5 weeks ago by tolkien

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