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Is CBD a Miracle Cure or a Marketing Scam? (Both.) - Reason.com
A recent migraine clinical trial, for instance, used 200 milligrams of CBD daily. A highly rated and reviewed one-ounce bottle of hemp oil I found online delivers 8.33 milligrams of CBD per serving and contains a total of 30 servings. A person would need to consume nearly a bottle per day to achieve the therapeutic effects seen in peer-reviewed CBD studies.

Various CBD products available on Amazon contain roughly the same amount or a few milligrams more per dose—still nowhere close to the therapeutic doses used in research.

Several studies have shown that CBD has a "bell-shaped dose-response curve," as one Brazilian report notes. In that study, which tested CBD as a treatment for anxiety in adults, 57 men were divided into four groups and given three different doses of CBD, plus a placebo. The group that received 300 mg of CBD had the best results, while the placebo group, the 150 mg group, and the 600 mg group fared much worse. There is, in other words, a sweet spot.

There's no question that the explosion of CBD products is creating serious confusion, and consumers are left to try to sort the wheat from the chaff without a lot of help"

While it does contain trace amounts of cannabidiol, all of the clinical research into CBD to date has used derivatives of the marijuana plant, not hemp.

"Many lower-quality producers use hemp oil imported from overseas," West explains in an email. The vast majority of CBD products available on sites like Amazon, for instance, use CBD derived from hemp, and many vendors are not clear about where that hemp was grown.

Consumers know only what they see on the label and in most cases have no third party to help them make decisions. As a result, the paper's authors warned, consumers are ignorant of the "residual presence of toxic solvents used during the extraction procedure" and do not know whether a formulation contains heavy metals absorbed from soil, excessive pesticides sprayed on the plants themselves, or non-CBD drugs designed to give users the sense that the product "works." In 2016, the Food and Drug Administration (FDA) tested 13 different CBD products and found that only two of them contained the amount of CBD listed on the label.

the market has been flooded with crappy products created by companies, both foreign and domestic, hoping to cash in on the hype.

It is against the law for any researcher in the U.S. to test a domestic CBD formulation against Epidiolex in a randomized, controlled trial.
Every year, the FDA sends hundreds of warnings like that one to manufacturers across the United States. What made its letter to the Stanleys so remarkable is that the brothers had created a drug that demonstrably treats the seizures associated with Dravet syndrome but were being told they could not say so. "To be in good standing with the Food and Drug Administration's (FDA) regulations, we simply cannot speak about our product in relation to any disease."

"Researchers in the United States face cumbersome and antiquated barriers to studying CBD, THC, and other compounds contained in marijuana, in part because the Controlled Substances Act has installed cops and prosecutors as the arbiters of what scientists and doctors can investigate and learn."
CBD  marijuana  confusion  research  treat  seizure  epilepsy  against  FDA 
4 weeks ago by dandv
Why is 11 am + 1 hour == 12:00 pm?
on the English Language Learners Stack Exchange
time  standards  confusion  clock 
may 2018 by mirthe
Please STOP confusing Wi-Fi with 5G | LinkedIn
interesting arguments that justify why the confusion between both terms is being created
5G  WiFi  confusion 
february 2018 by creym
Miller-Nicely, 1955
"Miller, George A. and Nicely, Patricia, ``An Analysis of Perceptual Confusions among some English Consonants'', J.Acoust.Soc.Am. 27:2, 1955.
5 female English subjects alternated as speaker and listeners in a classic experiment involving the consonants /ptkbdgfvsSzZmn/ in CV utterances, V being the vowel /a/ in 'father'. /S/ and /Z/ are the middle phonemes in 'pushing' and 'measure' respectively. Several S/N and frequency bands were tested, only a few of which are given here."
speech  phonetics  consonant  confusion 
january 2018 by arsyed
Flabbergasted! Quote Of The Year From Berkshire Hathaway's Charlie Munger
"This has basically never happened before in my whole life. I can remember 1½ percent rates. It certainly surprised all the economists. It surprised the people who created the life insurance industry in Japan, who basically all went broke because they guaranteed to pay a 3% interest rate. I think everybody’s been surprised by it, including all the people who are in the economics profession who kind of pretend they knew it all along. But I think practically everybody was flabbergasted. I was flabbergasted when they went low; when they went negative in Europe – I’m really flabbergasted. How many in this room would have predicted negative interest rates in Europe? Raise your hands. [No hands go up]. That’s exactly the way I feel. How can I be an expert in something I never even thought about that seems so unlikely. It’s new territory....

"I think something so strange and so important is likely to have consequences. I think it’s highly likely that the people who confidently think they know the consequences – none of whom predicted this – now they know what’s going to happen next? Again, the witch doctors. You ask me what’s going to happen? Hell, I don’t know what’s going to happen. I regard it all as very weird. If interest rates go to zero and all the governments in the world print money like crazy and prices go down – of course I’m confused. Anybody who is intelligent who is not confused doesn’t understand the situation very well. If you find it puzzling, your brain is working correctly.”

– Charles Munger, age 91, vice chairman of Berkshire Hathaway BRK.B +0% on 3/25/2015
quotes  charlie_munger  confusion 
january 2018 by rnschmidt

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