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CannabisoilHealingForAnimals  CannabisHealing 
june 2018 by juandante
How Does CBD Affect the Endocannabinoid System?
How Does CBD Affect the Endocannabinoid System?

The endocannabinoid system exists to respond to endogenous cannabinoids produced by the human body. However, scientists have learned that the system will also recognize and respond to cannabinoids from external sources, including the phytocannabinoid cannabidiol. According to the National Institutes of Health, manipulating the endocannabinoid system by introducing external cannabinoids like CBD could be useful in treating a variety of medical ailments.

CBD and Cannabinoid Receptors

The endocannabinoid system includes two primary types of receptors that bind to cannabinoids: CB1 and CB2. Unlike THC, which fits directly into the CB1 receptor, cannabidiol does not fit into either type of receptor perfectly. Instead, it stimulates activity in both receptors without actually binding to them. This results in changes within any cells that contain either receptor. Because CB1 and CB2 receptors are present throughout the body, the effects of CBD are systemic.

According to Project CBD, research has also shown that CBD counteracts the psychoactive effects of THC by inhibiting its effects on CB1 receptors.

CBD's Indirect Effects on the Endocannabinoid System

When introduced into the endocannabinoid system, CBD causes an increased release of 2-AG, one of the endogenous cannabinoids. Like CBD, 2-AG stimulates both CB1 and CB2 receptors, which enhances the overall effect on the body. Studies published by the National Institutes of Health have shown that cannabidiol also inhibits the activity of fatty acid amide hydroxylase, or FAAH. This slows the deterioration of anandamide, another important endogenous cannabinoid found naturally within the body.

Other Effects of CBD

In addition to its impact on the endocannabinoid system, CBD also affects the body in other ways. For example, CBD binds directly to a G-protein coupled receptor known as TRPV-1, which is responsible for mediating body temperature, perceptions of pain and inflammation. CBD also activates serotonin receptors. Furthermore, studies conducted by the California Pacific Medical Center have shown that cannabidiol has the power to inhibit the ID-1 gene, which is known to cause several aggressive cancers, including certain cancers of the breast, brain, lungs, ovaries and pancreas.

Implications in Medicine

Cannabidiol's impact on the endocannabinoid system, as well as its other effects on the human body, indicate that this substance may be useful in treating a variety of medical conditions. For example, the medical community has already identified that THC can be an effective treatment for multiple ailments, including the side effects of chemo. Because CBD inhibits the negative effects of THC, it stands to reason that administering the two substances together could be even more beneficial than treatment with THC alone. Likewise, cannabidiol's stimulation of the endocannabinoid system promotes homeostasis within the body, reduces sensations of pain and inhibits inflammatory processes. Finally, CBD's effects on other genes and systems, such as its inhibition of the ID-1 gene, indicate that it may be an ideal treatment for certain types of effective cancers.

Medical research involving the possible uses of CBD is ongoing, the list of conditions CBD could potentially treat continues to grow. Currently, the list includes the conditions listed above, as well as mood disorders, diabetes, heart disease, glaucoma, asthma, stroke and many more.

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EndocannabinoidSystem  CBD  CannabisHealing  CannabisOilHealing 
june 2018 by juandante
The Science of the Endocannabinoid System: How THC Affects the Brain and the Body First published 2011
After several decades of research, scientists studying the effects of marijuana made several important discoveries. Not only did they identify the active ingredient in marijuana, they also discovered where and how it works in the brain—via a new system they called the endocannabinoid (EC) system. The EC system—named after the marijuana plant Cannabis sativa and its active ingredient delta-9-tetrahydrocannabinol (THC)—is a unique communications system in the brain and body that affects many important functions, including how a person feels, moves, and reacts.

The natural chemicals produced by the body that interact within the EC system are called cannabinoids, and like THC, they interact with receptors to regulate these important body functions. So what makes the EC system unique and how does THC’s impact on this system affect a person’s memory, risk for accidents, and even addiction?

Review Figure 1 and the steps below to take a closer look at the components of the EC system, how it works, and the effects of THC.
EndocannabinoidSystem  THC  CannabisHealing  CannabisOilHealing 
june 2018 by juandante
How Cannabis Oil Works to Kill Cancer Cells by Dennis Hill
"First let’s look at what keeps cancer cells alive, then we will come back and examine how the cannabinoids CBD (cannabidiol) and THC (tetrahydrocannabinol) unravels cancer’s aliveness.
"In every cell there is a family of interconvertible sphingolipids that specifically manage the life and death of that cell. This profile of factors is called the “Sphingolipid Rheostat.” If endogenous ceramide(a signaling metabolite of sphingosine-1-phosphate) is high, then cell death (apoptosis) is imminent. If ceramide is low, the cell is strong in its vitality.
"Very simply, when THC connects to the CB1 or CB2 cannabinoid receptor site on the cancer cell, it causes an increase in ceramide synthesis which drives cell death. A normal healthy cell does not produce ceramide in the presence of THC, thus is not affected by the cannabinoid.
"The cancer cell dies, not because of cytotoxic chemicals, but because of a tiny little shift in the mitochondria. Within most cells there is a cell nucleus, numerous mitochondria (hundreds to thousands), and various other organelles in the cytoplasm. The purpose of the mitochondria is to produce energy (ATP) for cell use. As ceramide starts to accumulate, turning up the Sphingolipid Rheostat, it increases the mitochondrial membrane pore permeability to cytochrome c, a critical protein in energy synthesis. Cytochrome c is pushed out of the mitochondria, killing the source of energy for the cell...."
CannabisHealing  CannabinoidMedicine  CannabisOil  CancerHealing  CancerHealingTreatment 
may 2018 by juandante
OH MY SCIENCE There’s a surprising link between coffee and cannabis by Marla Paul | Northwestern
Scientists were surprised to discover coffee changed many more metabolites in the blood than previously known.

New research shows coffee can affect our metabolism in dozens of ways—including our metabolism of steroids and the neurotransmitters typically linked to cannabis—beyond the caffeine boost we expect in the morning.

“These are entirely new pathways by which coffee might affect health.”

After drinking four to eight cups of coffee in a day, people’s neurotransmitters related to the endocannabinoid system—the same ones that cannabis affects—decreased. That’s the opposite of what occurs after someone uses cannabis.

Neurotransmitters are the chemicals that deliver messages between nerve cells and cannabinoids are the chemicals that give the cannabis plant its medical and recreational properties. Our body also naturally produces endocannabinoids, which mimic cannabinoid activity.

Further, certain metabolites related to the androsteroid system increased after drinking four to eight cups of coffee in a day, which suggests coffee might facilitate the excretion or elimination of steroids. Because the steroid pathway is a focus for certain diseases including cancers, coffee may have an effect on these diseases as well, researchers say.

“These are entirely new pathways by which coffee might affect health,” says lead author Marilyn Cornelis, assistant professor of preventive medicine at Northwestern University Feinberg School of Medicine. “Now we want to delve deeper and study how these changes affect the body.”

Little is known about how coffee directly impacts health. In the new study, which appears in the Journal of Internal Medicine, scientists applied advanced technology that allowed them to measure hundreds of metabolites in human blood samples from a coffee trial for the first time.

For the study, 47 people in Finland didn’t drink coffee for one month, then consumed four cups a day for the second month, and then eight cups a day for the third month. Researchers used advanced profiling techniques to examine more than 800 metabolites in the blood collected after each stage of the study.

Blood metabolites of the endocannabinoid system decreased with coffee consumption, particularly with eight cups per day.

The endocannabinoid metabolic pathway is an important regulator of our stress response, Cornelis says, and some endocannabinoids decrease in the presence of chronic stress.

“The increased coffee consumption over the two-month span of the trial may have created enough stress to trigger a decrease in metabolites in this system,” Cornelis says. “It could be our bodies’ adaptation to try to get stress levels back to equilibrium.”

Sweet, low-calorie foods confuse our metabolism
The endocannabinoid system also regulates a wide range of functions: cognition, blood pressure, immunity, addiction, sleep, appetite, energy, and glucose metabolism.

“The endocannabinoid pathways might impact eating behaviors…the classic case being the link between cannabis use and the munchies.”

The brew also has been linked to aiding weight management and reducing risk of type 2 diabetes.

“This is often thought to be due to caffeine’s ability to boost fat metabolism or the glucose-regulating effects of polyphenols (plant-derived chemicals),” Cornelis says. “Our new findings linking coffee to endocannabinoids offer alternative explanations worthy of further study.”

The American Diabetes Association, the German Federal Ministry of Health, and other sources funded the work.

This article was originally published at northwestern.edu and republished here under the Creative Commons Attribution 4.0 International license.
Cannabis  Coffee  EndocannabinoidSystem  CannabisHealing 
may 2018 by juandante
This MAN Healed 5000 People from Cancer: This Is a Recipe That Kills Tumors in 90 Days
"Hemp or cannabis oil was used by numerous people for centuries, but it was banned in the second half of the 20th century, as a result of the rise of the billion-dollar pharmaceutical industry.
"Rick Simpson is a mechanical engineer and a self-taught doctor, who was diagnosed with skin cancer in 2002 and fought this disease using this miraculous oil. Nowadays, he is one of the greatest world activists for legalization of hemp oil. Using this treatment, he has cured over 5,000 people.
"He attended a debate organized in Belgrade, the capital of Serbia, on this topic. He states that hemp or cannabis oil can cure a vast variety of serious health issues, like diabetes, arteriosclerosis, multiple sclerosis, epilepsy, asthma, psoriasis, as well as some of the deadliest forms of cancer.
"Rick recounted his story to the Serbian magazine Telegraph “I always tell people – Cannabis will cure you, and you will see that at present, it is the best cure there is in the world!”
"He began his story: “It was 2002. The doctors had given up on me because I’d had more than one unsuccessful operation on three pigmented lesions on my face’s skin. As soon as these were removed, they would reappear even more infected! Since I had been studying plants as a hobby for years, one day as I was looking at my wounds in the mirror, I remembered a study from the University of Virginia that said that THC, an active component of cannabis could cure cancer. I took some cannabis oil I had prepared beforehand from the cabinet and dripped a few drops directly on the wound.”
"No significant results could be noticed at first. He bandaged his wounds again after applying the oil and waited for few days.
"Then, he went on: “After four days I removed the bandages and I couldn’t believe my eyes! The wound was no longer there, and my skin was regenerated! I immediately started talking to people about how I had cured skin cancer with cannabis oil… Everyone laughed at me, but then eleven and a half years have passed, and the cancer still hasn’t returned.”
"From then on, Simpson decided to help people in need for this cure, and his work resulted in thousands of cases effectively solved. His last case was an 80-year-old man who was dying from lung cancer...."
RickSimpson  RickSimpsonOil  CannabisHealing  CannabisOil  CannabisOilHealingDocumentation 
november 2017 by juandante
How Cannabis Oil Works to Kill Cancer Cells
First let’s look at what keeps cancer cells alive, then we will come back and examine how the cannabinoids CBD (cannabidiol) and THC (tetrahydrocannabinol) unravels cancer’s aliveness.

In every cell there is a family of interconvertible sphingolipids that specifically manage the life and death of that cell. This profile of factors is called the “Sphingolipid Rheostat.” If endogenous ceramide(a signaling metabolite of sphingosine-1-phosphate) is high, then cell death (apoptosis) is imminent. If ceramide is low, the cell is strong in its vitality.

Very simply, when THC connects to the CB1 or CB2 cannabinoid receptor site on the cancer cell, it causes an increase in ceramide synthesis which drives cell death. A normal healthy cell does not produce ceramide in the presence of THC, thus is not affected by the cannabinoid.

The cancer cell dies, not because of cytotoxic chemicals, but because of a tiny little shift in the mitochondria. Within most cells there is a cell nucleus, numerous mitochondria (hundreds to thousands), and various other organelles in the cytoplasm. The purpose of the mitochondria is to produce energy (ATP) for cell use. As ceramide starts to accumulate, turning up the Sphingolipid Rheostat, it increases the mitochondrial membrane pore permeability to cytochrome c, a critical protein in energy synthesis. Cytochrome c is pushed out of the mitochondria, killing the source of energy for the cell. - See more at: http://www.cureyourowncancer.org/how-cannabis-oil-works.html#sthash.biq49Wd8.dpuf
CannabisOil  CannabisHealing  CancerHealing 
february 2017 by juandante
Stoney Girl Gardens | Gro4Me.com
Adrienne Leasa's choice for best CO website on the Internet 12.24.15]
CannabisOilWebsites  CannabisHealing  Delicious 
december 2015 by juandante
New Study Proves Cannabis Extract Has Effect on Brain Tumors By Cannabis Now on ...
A new study released by the University of St. GeorgeΓÇÖs London is showing that cannabis can produce significantly positive results in brain cancer patients. THC and CBD, the chemically-active components in marijuana, are also known as phytocannabinoids. When these two compounds are combined with irradiation or radio therapy, they have drastic and life-saving effects that are shown to shrink tumors or make them disappear altogether. Doctor Wai Liu, the Senior Research Fellow and lead researcher for the project made sure that the research approached the complex issue from the number of angles and experimented with a number of combinations to assure the data was thorough. ΓÇ£The results are extremely exciting. The tumours were treated in a variety of ways, either with no treatment, the cannabinoids alone, and irradiation alone or with both the cannabinoids and irradiation at the same time,ΓÇ¥ he said.
CannabisHealing  CannabisOil  CancerHealings  Tumors  CancerTumors  BrainTumors  Delicious 
march 2015 by juandante
Strains - Weed Wiki ~ Indica and Sativa ~ Differences and Various Strains of eac...
Cannabis indica (indica) plants typically grow short and wide, making them better suited for indoor growing. Consuming indicas will produce a more physical body high that can make users sleepy or "couch-locked" and induce a feeling of relaxation. Following is a list of indica strains: Afgoo / Afgooey BC God Bud Berry UW Blue Cheese Bubba Kush Bullrider God's Gift Hashplant Hindu Kush Killer Purple MK-Ultra Northern Lights Oregon Kid Blackberry Kush Private Reserve OG Purple Afghani Purple Goo Purple Kush Purple Urkel Red Stem Afghani Romulan Sensi Star Skywalker OG Strawberry Diesel Supernatural Vanilla Kush Sativa Strains Jack Herer Purple Haze Cannabis sativa (sativa) plants grow tall and thin, making them better suited for outdoor growing. The high produced from consuming sativas is more energetic and uplifting. Following is a list of sativa strains: Acapulco Gold Alaskan
WeedWiki  Cannabis  IndicaStrains  SativaStrains  Marijuana  MedicalMarijuana  CannabisOil  CannabisHealing  AlaskanThunderfuck  MatanuskaThunderfuck  Delicious 
december 2014 by juandante
CannabisHealingMedical Marijuana Dispensaries, Cannabis Club Directory - Pot Law...
Medical Marijuana & A Better Tomorrow Medical marijuana is gaining momentum worldwide as a natural medicine that provides safe alternatives to treatment by toxic chemicals. The purpose of this website is to promote education in regards to medical marijuana and to provide an interactive platform for discussion and collaboration. As advocates of all forms of marijuana legalization, it is our mission to provide a place for groups and organizations to come together as one, working towards a common goal. We pledge to assist in changing the medical marijuana laws nationwide and educating others about marijuana... prohibition must end. Together, our numbers cannot be denied, and it is together that we shall overcome. - Tres Hombres
MedicalMarijuana  CannabisOil  CannabisHealingCancer  CannabisHealing  CannabisOilDocumentedHealing  CannabisMedicineDataBase  CannabisMedicine  CannabisOilDocumentation  Delicious 
december 2014 by juandante
700 MEDICINAL USES OF CANNABIS SORTED BY DISEASE - A collection of clinical stud...
A collection of clinical studies, papers and reference providing the ultimate resource for medical disorders helped by medical marijuana. If a link doesnΓÇÖt work , try Weedbay
MedicalMarijuanaResearch  CannabisClinicalStudies  CannabisHealing  EndocannabinoidSystem  MarijuanaClinicalStudies  MarijuanaResearch  Delicious 
september 2014 by juandante
Molecular Biologist Explains How THC Completely Kills Cancer Cells | Collective-...
Below is a video of Dr. Christina Sanchez, a molecular biologist at Compultense University in Madrid, Spain, clearly explaining how THC (the main psychoactive constitute of the cannabis plant) completely kills cancer cells. Not long ago, we published an article examining a case study recently published where doctors used cannabis to treat Leukemia, you can read more about that here. To read more articles and view studies about how cannabis is an effective treatment and cure for cancer, click here. Cannabinoids refer to any group of related compounds that include cannabinol and the active constituents of cannabis. They activate cannabinoid receptors in the body. The body itself produces compounds called endocannabinoids and they play a role in many processes within the body that help to create a healthy environment. I think itΓÇÖs also important to note that cannabis has been shown to treat cancer without any psychoactive effects. Cannabinoids have been proven to reduce cancer cells a
cancer  CannabisHealing  CannabisHealingCancer  Cannabinoids  CannabisOil  Delicious 
august 2014 by juandante
Cannabis Science Cannabinoid Compounds Marijuana Documentary [Full Video] - YouT...
Published on Jan 25, 2014 Cannabis Science Cannabinoid Compounds Marijuana Documentary [Full Video] Cannabis Science Cannabinoid Compounds Marijuana Documentary [Full Video] Cannabis Science Cannabinoid Compounds Marijuana Documentary [Full Video] Cannabis Science Cannabinoid Compounds Marijuana Documentary [Full Video] Cannabis Science Cannabinoid Compounds Marijuana Documentary [Full Video] Cannabis Science Cannabinoid Compounds Marijuana Documentary [Full Video] Cannabis Science Cannabinoid Compounds Marijuana Documentary [Full Video]
CannabisDocumentaries  EndocannabinoidSystem  CannabisOil  CannabisHealing  CannabinoidMedicine  Cannabinoids  Delicious 
august 2014 by juandante
Bluebird Botanicals CBD Hemp Oil ~ Colorado Hemp Oil Producer
ABOUT OUR CBD HEMP OIL: MAIN INGREDIENT: cannabidiol (CBD) extract The main ingredient in our CBD Hemp oil is a cannabidiol (CBD) extract derived from the industrial cultivation of Cannabis sativa. Industrial hemp is ideal for cannabidiol (CBD) extractions as it is naturally high in CBD and low in THC, making it superior to most high-THC strains as far as CBD content is concerned. The hemp we use is grown on family farms in countries where it is legal to do so, and is done under the regulation of the governing bodies in those countries. Hemp, because of it's innate ability to thrive so easily, doesn't require pesticides, fertilizers, or herbicides in it's cultivation, and barely needs water compared to standard commercial farming. Our hemp is NON-GMO and is grown under the same methods and standards of organic farming, but at this time there is no actual legal procedure for the organic certification of hemp cultivation. We're expecting the process for organic certification of hemp t
BluebirdBotanicals  HempOil  MedicalMarijuana  HempOilSuppliers  CannabisHealing  Hemp  Cannabidiols  CBD  Delicious 
february 2014 by juandante
Internet Archive Search: cannabinoid medicine
Cannabinoid Conference 2011 6th Conference on Cannabinoids in Medicine and 5th European Workshop on Cannabinoid Research, September 8-10, 2011 University of Bonn, Germany: http://www.bonn2011.org/ International Association for Cannabinoid Medicines: http://cannabis-med.org Program and Abstracts (PDF): http://www.cannabis-med.org/meeting/Bonn2011/abstractbook.pdf Keywords: Cannabinoids; Cannabinoid; Conference; Bonn; 2011; Bonn2011; IACM; Medicine; European; Workshop; University; Research; Programs; Abstracts; Abstractbook Downloads: 459 [texts] Cannabinoid Conference 2011 Poster - IACM 6th Conference on Cannabinoids in Medicine and 5th European Workshop on Cannabinoid Research, September 8â10, 2011 Bonn 2011: http://www.bonn2011.org/ Conference Poster: http://www.cannabis-med.org/meeting/Bonn2011/poster.pdf Keywords: Cannabinoid; Conference; Poster; 2011; Bonn; Bonn2011; IACM; Workshop Downloads: 29 [texts] Cannabinoid Conference 2013 7th Conference on Cannabinoids in Medicine27-28 S
Cannabinoids  CannabinoidMedicine  CannabisHealing  MedicalMarijuana  CannabisMasterDataBase  CannabisMedicineDataBase  Delicious 
january 2014 by juandante
Endocannabinoids in the immune system and cancer.
[Prostaglandins Leukot Essent Fatty Acids. 2002 Feb-Mar] - PubMed - NCBI.... The present review focuses on the role of the endogenous cannabinoid system in the modulation of immune response and control of cancer cell proliferation. The involvement of cannabinoid receptors, endogenous ligands and enzymes for their biosynthesis and degradation, as well as of cannabinoid receptor-independent events is discussed. The picture arising from the recent literature appears very complex, indicating that the effects elicited by the stimulation of the endocannabinoid system are strictly dependent on the specific compounds and cell types considered. Both the endocannabinoid anandamide and .....
EndocannabinoidSystem  MedicalMarijuana  CannabisHealing  ImmuneSystem  CannabisResearch  PubMed  Delicious 
january 2014 by juandante
Shocking Results: Woman Replaces 40 Medications With Raw Cannabis Juice ~ www.co...
There is also a large amount of evidence supporting the fact that cannabis can also be an effective treatment, and even a potential cure for cancer. We provided a list of 20 medical studies that prove cannabis can cure cancer(2). We already know that prescription drugs kill over 100,000 people each year and that a plant-based diet can prevent over 60% of chronic disease deaths. ItΓÇÖs time to lose our stigmatism about cannabis, the only reason weΓÇÖve been made to look at it in a negative manner is because it would threaten multiple industries (including the pharmaceutical industry). Cannabis along with hemp has over 50,000 uses and could help transform our world.
CannabisOilHealingDocumentation  CannabisOil  CannabisJuice  CannabisSmoking/Vaporizing  CannabisHealing  Delicious 
december 2013 by juandante
Watch the amazing change when this woman with cerebral palsy smokes pot
Link received from Denny as Facebook message 12.10.13 Jacqueline Patterson was born with cerebral palsy, a congenital disorder that affects her motor functions. As a result of her condition, she suffers from a severe stutter and major pain and weakness on her right side. This video showcases the amazing effect of cannabis on her condition.
marijuana  MedicalMarijuana  CannabisHealing  Stuttering  CerebalPalsey  DennyHayes  Delicious 
december 2013 by juandante

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