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Reproducibility Project: Cancer Biology | Collections | eLife
The Reproducibility Project: Cancer Biology is an initiative to independently replicate selected results from a number of high-profile papers in the field of cancer biology. For each paper a Registered Report detailing the proposed experimental designs and protocols for the replications is peer reviewed and published prior to data collection; the results of these experiments are then published as a Replication Study. The project is a collaboration between the Center for Open Science and Science Exchange.

The aim of the project is two-fold: to provide evidence about reproducibility in preclinical cancer research, and to identify the factors that influence reproducibility more generally. Interpreting the results reported in the Replication Studies requires a nuanced approach, as explained in this Editorial. To date four of the studies have reproduced important parts of the original papers; three of the studies have reproduced parts of the original papers but also contain results that could not be interpreted or are not consistent with some parts of the original paper; two of the studies could not be interpreted; and two studies did not reproduce the parts of the original papers that they attempted to reproduce.
cancer  reproducibility  Science  statistics 
3 days ago by cnk
Ultra96 Skin Cancer AI -
According to the Skin Cancer Foundation, half of the population in United States are diagnosed with some form of skin cancer by age 65. The survival rate for early detection is almost 98%, but it falls to 62% when the cancer reaches the lymph node and 18% when it metastasizes to distance organs. With Skin Cancer AI, we want to use power of artificial intelligence to provide early detection as widely as available.
medical  intel  ai  artificialintelligence  cancer  diagnostic 
3 days ago by cyberchucktx
Lethal combination: Drug cocktail turns off the juice to cancer cells
The widely used anti-diabetes drug metformin not only reduces blood sugar but also has an anti-cancer effect. However, the metformin dose commonly used in the treatment of diabetes is too low to inhibit cancer growth. The previous study of Prof. Hall's group at the University of Basel's Biozentrum revealed that the antihypertensive drug syrosingopine enhances metformin's anti-cancer efficacy
science  medicine  cancer 
6 days ago by emkay
» The Guardians of Memory (A finalist)
The first 1200 words from my novel, The Guardians of Memory is a finalist in the Writer Advice’s Scintillating Starts Contest. Hannah glides through the fog as if an apparition—beautiful and giving as if Jesus himself is pouring her out of a wine bottle. via Pocket
IFTTT  Pocket  cancer  patient-advocate 
6 days ago by basecamp
Pros and Cons of Dietary Strategies Popular Among Cancer Patients | Cancer Network
Oncology (Williston Park). 32(11):542-7

Suzanna Maria Zick, ND, MPH

Detrick Snyder, MPH

Donald I. Abrams, MD

Table. Definition of Dietary Patterns, Possible Nutrient Deficiencies, and Nutritional Counseling Tips

Figure. Comparison of Popular Cancer Diets From the American Cancer Society and American Institute for Cancer Research Dietary Guidelines

Abstract / Synopsis: 
As many as 48% of cancer patients pursue popular diets, including the alkaline, Paleolithic, ketogenic, vegan, and macrobiotic diets, with the hope that they will improve survival and prevent recurrence. These diets have positive aspects consistent with the dietary guidelines proposed by the American Cancer Society (ACS) and the American Institute for Cancer Research (AICR). All of the diets emphasize eating vegetables, all but the ketogenic diet encourage eating fruit, and all but the vegan diet limit refined grains and alcohol. Both the macrobiotic and the alkaline diets meet the majority of the ACS and AICR guidelines. Negative aspects of these diets include pseudo-scientific rationales for their anti-cancer properties, limited evidence that they improve cancer outcomes, the possibility for nutrient insufficiencies, and elimination of food groups proven beneficial for cancer prevention and general health. Moreover, with nutritional counseling, nutrient insufficiencies and misalignment with cancer clinical guidelines can often be addressed. Clinicians should consider strategies to encourage evidence-based dietary changes that encourage positive features of popular cancer diets, while minimizing negative aspects.
diet  cancer 
7 days ago by cnk
DEPLETED URANIUM Cancer as Weapon: Poppy Bush’s Radioactive War on Iraq If George Bush Sr., Dick Cheney, Colin Powell and Bill Clinton are still casting about for a legacy, there’s a grim one that will stay around for an eternity. by Jeffrey St. Clair
At the close of the first Gulf War, Saddam Hussein was denounced as a ferocious villain for ordering his retreating troops to destroy Kuwaiti oil fields, clotting the air with poisonous clouds of black smoke and saturating the ground with swamps of crude. It was justly called an environmental war crime.

But months of bombing of Iraq by US and British planes and cruise missiles has left behind an even more deadly and insidious legacy: tons of shell casings, bullets and bomb fragments laced with depleted uranium. In all, the US hit Iraqi targets with more than 970 radioactive bombs and missiles.

It took less than a decade for the health consequences from this radioactive bombing campaign to begin to coming into focus. And they are dire, indeed. Iraqi physicians call it “the white death”-leukemia. Since 1990, the incident rate of leukemia in Iraq has grown by more than 600 percent. The situation is compounded by Iraq’s forced isolations and the sadistic sanctions regime, recently described by UN secretary general Kofi Annan as “a humanitarian crisis”, that makes detection and treatment of the cancers all the more difficult.
IraqWar  DepletedUraniumWeapons  GeorgeHWBush  WarCrimes  Cancer 
9 days ago by juandante

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