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What Makes a Waterfall? Maybe It Forms Itself - The New York Times
An experiment with a river built in a lab suggests that geological histories around the world may need to be rewritten.
caltech  madison 
4 days ago by nearwalden
AbbVie Biotherapeutics director leads team against cancer - San Francisco Business Times
Diane Hollenbaugh

Senior director, discovery

Company: AbbVie Biotherapeutics

HQ: Redwood City

Years at company: 5

Raised by a physician and a chemist in Chicago and the Pacific Northwest, Hollenbaugh always followed the science that she found the most interesting. As an undergrad at University of Washington, it was chemistry. And after receiving her Ph.D. in chemistry from the California Institute of Technology and completing her post-doc training at the Bristol-Myers Squibb Pharmaceutical Research Institute in Seattle, it became immunology, the study of immune systems. That spawned an interest in immuno-oncology, an area of research that aims to activate the body’s own immune system to fight cancer.

Hollenbaugh has been deep in immunology since 1991 and in immuno-oncology for the past 15 years at companies like Medarex, FivePrime Therapeutics and Schering-Plough/Merck. In 2013, she joined AbbVie Biotherapeutics in Redwood City, where she leads a team of scientists focused on developing new medicines.
immunotherapy  Caltech  Business 
5 weeks ago by cnk
Autism and Theory of Mind | Caltech
The new test developed by Adolphs and Stanley's team is much more complex. In the new test, a participant learns about a person who is playing a particular game. The player—let's call her Sally—has some money and must decide whether to donate it to one of three charities or keep it for herself. Sally has some preferences about which charities she likes and which she does not. She is also switching back and forth between two "environments," a "reversal" environment in which her actions mostly have the opposite effect (i.e., donating money actually means she gets to keep it), and a "normal" environment, where things mostly go as expected. Sally does not know for sure which environment she is in, so she has to keep track of what happens to her decisions and take this into account when deciding about donating her money.

The individual actually taking the test watches what Sally does and must learn from her decisions to make inferences about her beliefs and preferences in order to predict her future actions. Does Sally believe she is in a normal or a reversal world? Which charities does she like? Which does she dislike? What will she do?

While this task is complex and difficult, adults with and without autism can understand it once it has been thoroughly explained and practiced. However, people with autism who took the test failed at one particular part: they could track Sally's beliefs about the environment and make logical conclusions about her behavior, but they could not learn which charities Sally intended to donate to and when she would keep the money for herself. 

"This task gives us the ability to deconstruct these different components of theory of mind and see that it's not basic learning or the logical reasoning component that's impaired in people with autism. What seems to break down is actually the specific ability to take into account someone's beliefs when you're interpreting their actions," says Stanley. "This more detailed understanding of how theory of mind can be impaired, in turn, gives us more purchase on how we could develop treatments in the future."

"This test is very valuable because in reality people learn over time about others' changing beliefs from watching what they do," says Rosenthal. "So the task, although complex, in fact tries to approximate what happens in the real world—which is, after all, what we're ultimately interested in explaining." 
Caltech  psychology 
7 weeks ago by cnk
Welcome to Agilent Careers
Job Description
Agilent inspires and supports discoveries that advance the quality of life. We provide life science, diagnostic and applied market laboratories worldwide with instruments, services, consumables, applications and expertise. Agilent enables customers to gain the answers and insights they seek ---- so they can do what they do best: improve the world around us. Information about Agilent is available at
The Agilent Genomics group is an established leader in providing robust reagents and analysis solutions to the next-generation sequencing (NGS) market. Our team remains committed to offeringour NGS customers cutting-edgeproducts and workflow solutions through our continued development efforts. We are looking for new team members excited to join our cross-functional program focused on expanding Agilent NGS capabilities. This is youropportunity to actively contribute in a fast-paced environment that encourages learning and expertise in this high-growth industry.

Position Summary/Overview: We are seeking a Bioinformatics/Software Engineer who will be responsible for developing and implementing novel algorithms and pipelines for analyzing large volumes of next-generation sequencing data as part of a multi-disciplinary team of scientists, engineers, and inventors. As part of the Agilent Genomics team, you will play a key role in the assay development process through development and implementation of novel genomics and molecular biology solutions for the research and clinical application fields.

Job Description, Position Roles/Responsibilities:

The Bioinformatics/Software Engineer will work closely with chemists, biologists, data analysts, software and database developers and hardware engineers to help assess and improve overall system performance in a wide range of scenarios. As part of this multidisciplinary team you will have access to, and the opportunity to improve, data at all stages of the assay development process.
jobs  caltech  genomics  Bioinformatics 
9 weeks ago by cnk
Harold Brown, Defense Secretary in Carter Administration, Dies at 91
Jan. 5, 2019 | The New York Times | By Robert D. McFadden.

Harold Brown, a brilliant scientist who helped develop America’s nuclear arsenal and negotiate its first strategic arms control treaty, and who was President Jimmy Carter’s secretary of defense in an era of rising Soviet challenges, died on Friday at his home in Rancho Santa Fe, Calif. He was 91.....As defense secretary from 1977 to 1981, Mr. Brown presided over the most formidable power in history: legions of intercontinental ballistic missiles and fleets of world-ranging bombers and nuclear submarines, with enough warheads to wipe out Soviet society many times over......In retrospect, experts say, the Carter administration and Mr. Brown maintained the strategic balance, countering Soviet aircraft and ballistic innovations by improving land-based ICBMs, by upgrading B-52 strategic bombers with low-flying cruise missiles and by deploying far more submarine-launched missiles tipped with MIRVs, or multiple warheads that split into independent trajectories to hit many targets......By the time he joined the Carter administration, Mr. Brown had played important roles in the defense establishment for two decades — in nuclear weapons research, in development of Polaris missiles, in directing the Pentagon’s multibillion-dollar weapons research program, and in helping to plot strategy for the Vietnam War as secretary of the Air Force.....He had been a protégé of Edward Teller, father of the hydrogen bomb, and his successor as head of the Lawrence Livermore Laboratory in California. He had been president of the California Institute of Technology; had worked for Presidents John F. Kennedy, Lyndon B. Johnson and Richard M. Nixon; and had been a delegate to the Strategic Arms Limitation Talks (SALT I). As the first scientist to become defense secretary, Mr. Brown knew the technological complexities of modern warfare. He began the development of “stealth” aircraft, with low profiles on radar. He accelerated the Trident submarine program and the conversion of older Poseidon subs to carry MIRVs. And, with an eye on cost-effectiveness, he and President Carter halted the B-1 bomber as a successor to the B-52. Mr. Brown laid the groundwork for talks that produced the Camp David accords, mediated by Mr. Carter and signed in 1978 by President Anwar el-Sadat of Egypt and Prime Minister Menachem Begin of Israel. ......In 1980, Mr. Brown helped plan a mission to rescue American hostages held by Iranians who seized the American Embassy in Tehran in November 1979.......Harold Brown was born in New York City on Sept. 19, 1927, the only son of Abraham Brown, a lawyer, and Gertrude Cohen Brown. From childhood he was considered a genius. At 15, he graduated from the Bronx High School of Science with a 99.52 average. At Columbia University, he studied physics and earned three degrees — a bachelor’s in only two years, graduating in 1945 with highest honors; a master’s in 1946; and a doctorate in 1949, when he was 21.....From 1961 to 1965, he was director of defense research and engineering, the Pentagon’s third-ranking civilian, responsible for weapons development, and one of Defense Secretary Robert S. McNamara’s “whiz kids.” He was the Air Force secretary from 1965 to 1969, and over the next eight years he was president of the California Institute of Technology in Pasadena.

After leaving the Pentagon in 1981, Mr. Brown taught at the Paul H. Nitze School of Advanced International Studies at Johns Hopkins University for several years, and from 1984 to 1992 he was chairman of the school’s foreign policy institute.

Since 1990, he had been a partner at Warburg Pincus, the New York investment firm.
'60s  '70s  Caltech  Colleges_&_Universities  Jimmy_Carter  leadership  obituaries  Pentagon  physicists  SAIS  SecDef  security_&_intelligence  the_best_and_brightest  Vietnam_War  whiz_kids  Cold_War  public_servants 
11 weeks ago by jerryking
HOK's Facelift of Ronald and Maxine Linde Hall of Mathematics and Physics is Far from Formulaic
Project Team: Pam Light; Lisa Krutky Reed; Jennifer Ligon: HOK. Saiful Bouquet: Structural Engineer. P2S: Mechanical Engineer, Plumbing Engineer. Morrow-Meadows Cor­poration: Electrical Engineer. Hathaway Dinwiddie Construction Company: General Contractor.
HOK  2018  CalTech  education  LosAngeles  Goetz  Interiors 
december 2018 by hoknetwork

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