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Timing May Be Everything When Using Electrical Brain Stimulation to Boost Your Memory
TDCS might work best when the brain is foggy, and be counterproductive when the mind is already sharp
brain 
14 hours ago by magnusc
GREAT LEADERSHIP: When “Fluff Triples Revenues – Goodthink Inc.
Our research has found that a positive brain is connected with increasing sales by 37%, productivity by 31%, and decreasing the negative effects of stress by 23%.

plus i believe creative activities make you happier, ergo more productive
productivity  brain  wickedbook  casestudies  art-in-business 
yesterday by mofox
The beautiful languages of the people who talk like birds
"Their unusual whistled speech may reveal what humanity’s first words sounded like." and also adds to our knowledge of how the brain processes language, and more.
-- David Robson
BBC | bbc.com | 25 May 2017
language  brain  culture 
2 days ago by tometaxu
Anti-PD-1 Therapy May Induce Response in Patients With Melanoma Brain Metastases | PracticeUpdate
BACKGROUND

There is limited data on the efficacy of anti-programmed death 1 (PD-1) antibodies in patients (pts) with melanoma brain metastasis (BM), particularly those which are symptomatic.

METHOD

We retrospectively assessed pts with melanoma BM treated with PD-1 antibodies, nivolumab and pembrolizumab. Clinicopathologic and treatment parameters were collected and outcomes determined for intracranial (IC) response rate (RR) using a modified RECIST criteria, with up to five IC target lesions used to determine IC response, disease control rate (DCR) and progression-free survival (PFS).

RESULTS

A total of 66 pts were identified with a median follow up of 7.0 months (range 0.8-24.5 months). A total of 68% were male and 45% BRAF V600 mutation positive. At PD-1 antibody commencement, 50% had an elevated LDH; 64% had local therapy to BM prior to commencing anti-PD1, of which 5% had surgical resection, 14% stereotactic radiosurgery (SRS), 18% whole-brain radiotherapy (WBRT), 27% had surgery and radiotherapy. Twenty-one per cent started anti-PD-1 as first line systemic therapy. No pt had prior anti-PD-1 treatment. The IC overall RR was 21 and DCR 56%. Responses occurred in 21% of pts with symptomatic BM. The median OS was 9.9 months (95% CI 6.93-17.74). Pts with symptomatic BM had shorter PFS than those without symptoms (2.7 vs 7.4 months, P=0.035) and numerically shorter OS (5.7 vs 13.0 months, P=0.068). Pts requiring corticosteroids also had a numerically shorter PFS (3.2 vs 7.4 months, P=0.081) and OS (4.8 vs 13.1 months, P=0.039).

CONCLUSIONS

IC responses to anti-PD-1 antibodies occur in pts with BM, including those with symptomatic BM requiring corticosteroids. Prospective trials evaluating anti-PD-1 therapy in pts with BM are underway.
RCC  immunotherapy  brain  nivolumab 
3 days ago by cnk
The atomic bomb considered as Hungarian high school science fair project • Slate Star Codex
Scott Alexander:
<p>A group of Manhattan Project physicists created a tongue-in-cheek mythology where superintelligent Martian scouts landed in Budapest in the late 19th century and stayed for about a generation, after which they decided the planet was unsuitable for their needs and disappeared. The only clue to their existence were the children they had with local women.

The joke was that this explained why the Manhattan Project was led by a group of Hungarian supergeniuses, all born in Budapest between 1890 and 1920. These included Manhattan Project founder Leo Szilard, H-bomb creator Edward Teller, Nobel-Prize-winning quantum physicist Eugene Wigner, and legendary polymath John von Neumann, namesake of the List Of Things Named After John Von Neumann.

The coincidences actually pile up beyond this. Von Neumann, Wigner, and possibly Teller all went to the same central Budapest high school at about the same time, leading a friend to joke about the atomic bomb being basically a Hungarian high school science fair project.

But maybe we shouldn’t be joking about this so much.</p>

This is an amazing post, which will lead you through teaching, the Manhattan Project, genetic disease, ghettos, to an amazing conclusion, and then a coda that will leave you slightly aghast. You can find backing for his conclusion in the location of much of the startup energy in the west outside America; his coda isn't necessarily the end.

Other material to read: <a href="https://newrepublic.com/article/77727/groups-and-genes">Steven Pinker on a similar topic</a>; <a href="https://twitter.com/AdamRutherford/status/868117923352784896">Adam Rutherford giving his opinion on this piece</a> (an example of Twitter at its best).
genetics  brain  jews 
3 days ago by charlesarthur
The Atomic Bomb Considered As Hungarian High School Science Fair Project | Slate Star Codex
Scott Alexander recounts the theory that the Ashkenazi Jews are genetically more intelligent (or were, before Hitler killed them all).
genetics  brain  ScottAlexander  SlateStarCodex  via:SlateStarCodex 
3 days ago by mcherm
Facebook establishes neuroscience centre dedicated to marketing studies | The Drum
Facebook is branching out into the field of neuroscience research with the creation of its own scientific lab dedicated to devising new marketing techniques for agencies, brands and media firms.
facebook  brain  neuroscience  marketing 
4 days ago by koenkas

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