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Effects of low-carbohydrate- compared with low-fat-diet interventions on metabolic control in people with type 2 diabetes: a systematic review including GRADE assessments | The American Journal of Clinical Nutrition | Oxford Academic
Glycated hemoglobin declined more in people who consumed low-carbohydrate food than in those who consumed low-fat food in the short term (MD: –1.38%; 95% CI: –2.64%, –0.11%; very-low-certainty evidence). At 1 y, the MD was reduced to –0.36% (95% CI: –0.58%, –0.14%; low-certainty evidence); at 2 y, the difference had disappeared. There is low to high (majority moderate) certainty for small improvements of unclear clinical importance in plasma glucose, triglycerides, and HDL concentrations favoring low-carbohydrate food at half of the prespecified time points. There was little to no difference in LDL concentration or any of the secondary outcomes (body weight, waist circumference, blood pressure, quality of life) in response to either of the diets (very-low- to high-certainty evidence).
Conclusions
Currently available data provide low- to moderate-certainty evidence that dietary carbohydrate restriction to a maximum of 40% yields slightly better metabolic control of uncertain clinical importance than reduction in fat to a maximum of 30% in people with T2D.
triglycerides  fat  low  diet  diabetes  T2D  type  2  blood  pressure  carbohydrates  carb  fasting  quality  of  life  glucose  carbohydrate  waist  circumference  biomarkers  peer-reviewed  research  human  in  vivo  correlation  effects  benefit  nutrition  clinical  trial  review  systematic 
5 weeks ago by Michael.Massing
(865) Universal credit's housing sanctions - you'll wish you didn't know - don't have nightmares ! - YouTube
minimum wage = cant afford rent
ask for housing benefit through universal credit
will be asked to work more hours and get higher pay, to get out of universal credit
if you do not, get sanctioned, thus you work, can't get find better work or more hours (35hrs +), can't pay rent ...
... so much for burning injustice
Universal  Credit  DWP  sanctions  welfare  state  UK  working  poor  poverty  trap  housing  benefit  support  minimum  wage  nasty  party  Austerity  neoliberalism  CON-servatives  Conservative  Theresa  May  tax  child  taxcredit  homeless  Homelessness  Council 
5 weeks ago by asterisk2a
Dietary carbohydrate intake and mortality: a prospective cohort study and meta-analysis - The Lancet Public Health
We studied 15 428 adults aged 45–64 years, in four US communities, who completed a dietary questionnaire at enrolment in the Atherosclerosis Risk in Communities (ARIC) study (between 1987 and 1989), and who did not report extreme caloric intake (<600 kcal or >4200 kcal per day for men and <500 kcal or >3600 kcal per day for women). The primary outcome was all-cause mortality. We investigated the association between the percentage of energy from carbohydrate intake and all-cause mortality, accounting for possible non-linear relationships in this cohort. We further examined this association, combining ARIC data with data for carbohydrate intake reported from seven multinational prospective studies in a meta-analysis. Finally, we assessed whether the substitution of animal or plant sources of fat and protein for carbohydrate affected mortality.

Findings

....In the ARIC cohort, after multivariable adjustment, there was a U-shaped association between the percentage of energy consumed from carbohydrate (mean 48·9%, SD 9·4) and mortality: a percentage of 50–55% energy from carbohydrate was associated with the lowest risk of mortality. In the meta-analysis of all cohorts (432 179 participants), both low carbohydrate consumption (<40%) and high carbohydrate consumption (>70%) conferred greater mortality risk than did moderate intake, which was consistent with a U-shaped association (pooled hazard ratio 1·20, 95% CI 1·09–1·32 for low carbohydrate consumption; 1·23, 1·11–1·36 for high carbohydrate consumption). However, results varied by the source of macronutrients: mortality increased when carbohydrates were exchanged for animal-derived fat or protein (1·18, 1·08–1·29) and mortality decreased when the substitutions were plant-based (0·82, 0·78–0·87).

Interpretation

Both high and low percentages of carbohydrate diets were associated with increased mortality, with minimal risk observed at 50–55% carbohydrate intake. Low carbohydrate dietary patterns favouring animal-derived protein and fat sources, from sources such as lamb, beef, pork, and chicken, were associated with higher mortality, whereas those that favoured plant-derived protein and fat intake, from sources such as vegetables, nuts, peanut butter, and whole-grain breads, were associated with lower mortality, suggesting that the source of food notably modifies the association between carbohydrate intake and mortality.

Funding: National Institutes of Health.
whole  grain  carb  carbohydrates  low  fat  loss  guidelines  nutrition  food  foods  protein  macronutrients  proportion  ratio  ketogenic  diet  ketosis  risk  benefit  peer-reviewed  research  human  in  vivo  correlation  mortality  morbidity  all-cause  meta-analysis  animal  meat  plant-based  prospective  large  cohort 
5 weeks ago by Michael.Massing
What Foods Have No Carbs? | POPSUGAR Fitness
Kind of a clickbaity headline, but some good info with sources about the risks of extreme/prolonged ketogenic eating and the benefits of the right carbs for health and longevity.
whole  grain  carb  carbohydrates  low  fat  loss  guidelines  nutrition  food  foods  protein  macronutrients  proportion  ratio  ketogenic  diet  ketosis  risk  benefit  peer-reviewed  research  human  in  vivo 
5 weeks ago by Michael.Massing
SPAs, PWAs and SSR | simplabs
Single Page Apps, Progressive Web Apps and classic Server side rendered websites are often seen as orthogonal approaches to building web apps where only one is best suited for a particular project and one has to make a choice to go with one of them. In this post we’ll explore why that doesn’t have to be the case, since all 3 approaches can actually be combined in order to achieve the best result.
progressive  webapplication  singlepage  advocacy  benefit  feature 
7 weeks ago by gilberto5757
Dietary Supplement Use, Nutrient Intake, and Mortality Among U.S. Adults | Annals of Internal Medicine | American College of Physicians
During a median follow-up of 6.1 years, 3613 deaths occurred, including 945 CVD deaths and 805 cancer deaths. Ever-use of dietary supplements was not associated with mortality outcomes. Adequate intake (at or above the Estimated Average Requirement or the Adequate Intake level) of vitamin A, vitamin K, magnesium, zinc, and copper was associated with reduced all-cause or CVD mortality, but the associations were restricted to nutrient intake from foods. Excess intake of calcium was associated with increased risk for cancer death (above vs. at or below the Tolerable Upper Intake Level: multivariable-adjusted rate ratio, 1.62 [95% CI, 1.07 to 2.45]; multivariable-adjusted rate difference, 1.7 [CI, −0.1 to 3.5] deaths per 1000 person-years), and the association seemed to be related to calcium intake from supplements (≥1000 mg/d vs. no use: multivariable-adjusted rate ratio, 1.53 [CI, 1.04 to 2.25]; multivariable-adjusted rate difference, 1.5 [CI, −0.1 to 3.1] deaths per 1000 person-years) rather than foods.
supplement  risk  variables  vitamins  minerals  metals  dietary  food  benefit  peer-reviewed  research  human  cohort  study  mortality 
8 weeks ago by Michael.Massing
Making adjuvant therapy decisions with uncertain data | Annals of Oncology | Oxford Academic
The purpose of adjuvant therapy—therapy given after the curative intent treatment of the primary cancer and in the absence of any measurable disease—is to reduce the risk of local and distant recurrence in order to reduce the complications of local failure (improve quality of life) and/or improve survival. This logic underlies the rational use for local therapies such as radiation, and systemic therapies such as chemo-, targeted- and immune-therapies. Recent trials in oncology highlight three issues in adjuvant therapy. First, is it good enough to improve disease-free survival (DFS) if that does not translate into overall survival (OS)? Second, what magnitude of DFS should we pursue? And, third, how should we use adjuvant drugs in settings without randomized controlled trials (RCTs)?
healthcare  cancer  adjuvant  locoregional  benefit 
9 weeks ago by PieroRivizzigno

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