A man wakes up in a ruined wasteland, without memories, without a name, without knowing the strange guy who claims to once have been an angel, or that he once had a little brother. All he knows is that the world is dying, everyone is lying to him, and that somehow, somewhere, something went terribly wrong. Because someone said Yes when they should have said No, and someone else paid the price.
269,437

The stress of filming the last four episodes of season 3 have caught up with Jensen, who blames his hallucinations on Dean's emotional roller coaster and his own lack of sleep. But a short break between the season finale and the shooting of his new movie fails to improve his mental state. He abandons the movie and becomes a recluse in Vancouver, fearing for his own sanity. Once he realizes that the hallucinations are real, and there's more than just his sanity at stake, Jensen contacts Jared, who may be the only person able to understand what Jensen's going through. Jared arrives in Vancouver just in time to save Jensen's life, but the danger threatening Jensen remains. Their lives become a race against time, and the show has brought them more than they'd bargained for. Jared has to keep Jensen alive for 43 days. Can they make it? ..... 70,806

Set after the boys went their separate ways. Sam called Dean to tell him that he was Lucifer’s vessel, only to have his brother tell him how much better they were apart. Hurt, and afraid, Sam did the only thing that he thought might work to keep Lucifer from claiming his vessel. Unfortunately, he woke up anyways. Only, when he woke, it was to find the Trickster of all people sitting on the bed across from him.

He hadn’t expected to see him of all people there, and he certainly hadn’t expected to find him in his car the next morning, announcing that he was going to be traveling with him. Together, they set out, one to try and stop this whole thing, and the other for reasons that he keeps to himself.

Loki’s open about his opinion that Sam is going to eventually say ‘yes’. To him, it’s not even a question To Sam, it’s the one thing he’s determined to keep from happening. 132,781

“To me, it will always remind myself of the fact that I control
what happens to my body, that I can control my body. It also means that
even though people will always see what they want to see, like a crow
instead of a raven, I will always know what it is, so I will know that
while people always see some guy in a wheelchair, I will remember that I
am Jared. And also... see how the wing is kind of stretched out? It’s
‘cause even though my wings may be broken... I know I’m still free...”
34,333

Total AU Dean Winchester was just your average joe working as a
mechanic in his hometown of Lawarance,KS when he met Sam Logan and
everything changed. No slash or wincest! Warning: mentions of past abuse
of a minor. .... 70,358

Jared Padalecki was sixteen when Earth was invaded, shattering
the world as he knew it. A year later, he was stunned when the leader of
the human resistance, Jensen Ackles, was captured by the aliens,
crushing the humans' last gasp of hope. Since then, Jared has made it
his life's mission to rescue and restore Jensen, even if he never
expects to get the chance to do either. But when that chance
unexpectedly comes, Jared has to overcome the obstacles that he's put in
his own way before he can work with his former hero, who's been a
captive for years. If they can overcome the ways they've both been
changed, they might be able to figure out a way to stop the invaders and
maybe even save the world. ... 64,263

Sequel

http://zuben-fic.livejournal.com/95304.html

Jared and Jensen are more than just co-stars but best friends
for life. So when Jensen is finally ready to tell Jared his biggest
secret, he never expects to be insulted and deprecated. Deeply hurt,
Jensen leaves, only to be terminally injured in an accident. Coming to
his senses, Jared regrets what has happened. While he struggles with his
bad conscience and prepares for Jensen´s death, he meets a young woman
who gives Jared the chance to make everything right again. If Jared can
fulfill four tasks in four years, Jensen´s life will be spared. Jared,
who would do everything to save Jensen´s life, agrees. His tasks brings
him to Shadowland, a place like Earth, but desolate, cold, and lonely.
Invisible in real world and struggling with Jensen´s fate and the
terrible role he played in the accident, all Jared has left are the
occasional visits he pays Jensen and the hope that he can make things
right again. ..... 58.832

for depressing, suicidal thoughts, also mentions of self-harm.
Warnings: Depressing, suicidal thoughts, also mentions of self-harm. Set
in season 8, spoilers for 9x03. Sam makes an unexpected discovery about
Dean. He's keeping a secret journal, in shape of series of cassettes,
for times he wasn't feeling so well. Maybe he didn’t know Dean as well
as he thought he did. But, suicide notes were the last thing on his
mind. .... 56,088

You know my name, you know my face, you'd know my heart, if you
knew my place." (Follow/Breaking Benjamin) When a not-so-fictional Dean
finds himself in a world where his brother is actually Jared, his
alleged filming partner, and he is supposed to be an actor on a TV show
rather than a hunter, things spin a lot further out of control than even
the Winchesters are used to. Can he find his way back to his own
reality or is nothing of what he remembers reality in the first place?
As Dean and Jared struggle to accept this new and unwanted situation, it
takes a long and painful trip for both of them to realize what they
have lost. But it's not always just about losing someone. .... 26,000

Dr. Jensen Ackles is a renowned neuro-psychologist and pioneer
surgeon in the field known as Mind Mapping, a procedure that involves
entering a coma patient's mindscape and sifting through their memories
and trauma to help the patient wake up from the coma. It’s a complex
procedure that requires strict rules and no lingering remnants of the
visit. But while working with his current patient—Jared Padalecki, male,
24, attempted suicide--Jensen discovers he’s in too deep. He’s formed a
dangerous emotional attachment to Jared that could have devastating
consequences. He finds himself in the difficult situation of risking his
own mind and sense of self by losing himself in Jared. But the more
memories he visits, and the more he gets to know Jared, the more Jensen
realizes how important it is that he save Jared’s life, whether it costs
Jensen his identity or not.
76,041

http://archiveofourown.org/works/4546152/chapters/10348446

Nick has never been anything more than a pawn, and he knows
that--but even a pawn, strategically placed, can change the game for
everyone. It's a world full of angels, demons, and humans all fighting
for control of the board. And while all he's really playing for is what
he was promised in the first place--peace that never seems to come--Nick
finds himself dragged back into a high-stakes game he can't afford to
lose. And, no matter how much he wants to break free, it becomes
increasingly clear that something buried deep inside him has changed, in
ways he can't possibly understand; ways that just might keep him
involved in the horrors that Heaven and Hell both inflict on humanity
and, in the end, make things better--or worse. Along the way, there are
friends and foes, wardens and protectors--and those who would try to use
him to shape the future they want to see, with or without his consent.
It begs the question--with truth and trust always in short supply, is
there ever any winner, in the end?
102,488

http://archiveofourown.org/works/4369910/chapters/9917705

Dean comes back from Purgatory and finds his brother
domesticated and withdrawn from the hunting life. Naturally he jumps to
the conclusion that Sam abandoned him to find his cursed normal while
Dean fought for his life. He should have known not to assume anything
when it came to his little brother. ... 7.440

Based on the film "Deliver Us From Evil" which is based on a
true story. New York police officer Dean Winchester investigates a
series of crimes. He and his partner, Jody Mills, join forces with an
unconventional priest (Sam Wesson), schooled in the rites of exorcism,
to combat the possessions that are terrorizing their city. ... 35,180

http://archiveofourown.org/works/4731527

It was supposed to be easy. Safe. His new neighbor, Jensen,
with his broad shoulders, the heavy metal band shirts, the dog tags and
all kinds of scars was not Jared's type. Wasn't even gay. It was
supposed to be a casual friendship. But somewhere between unsuccessful
dates with pretty young men and summer days spend on motorcycle rides or
watching cheesy 80s movies with Jensen, things changed for Jared.
Question was, had they changed for Jensen, too? .... 21,000

Dean’s a ghost but hey, Sam will get him back alive and in the
meantime, he’s right here, so it’s all okay, right? Right? What’s right
is the Winchester brother’s complicated, impossible codependent need to
fix it, regardless of the consequences. Set around 9:10, before they
find the Book of the Damned. ... 26,000

http://archiveofourown.org/works/4114468

Coda to "The Things They Carried." Contains Spoilers. Sam and
Dean have a Brother Moment after leaving Fayetteville. Sam contemplates
how he handled his side of the case and what the future may hold. ...
2.098

Warnings: Themes of depression, self-harm, suicide ideation.
Post Swan Song AU: If Dean can’t be sure of anything else in the world,
he can be sure of this - he was made for Sam. Made to take care of him,
protect him, look after him. If Sam is gone, then there is no purpose to
his existence. If Sam is gone, there is only one course of action - get
Sam back. This is the story of Sam and Dean finding their way back to
each other, driving down the highway, saving people, hunting things.
..... 32,433

http://archiveofourown.org/works/4152621/chapters/9368958

If Sam dies in the past, John won't be forced to sacrifice
himself for Dean after a car accident, Dean won't go to Hell, and
Lucifer's cage will stay shut. ..... Sam's family completely disagrees
.................... 4,355

After Sam walks away from Dean, he begins to wonder if there's
anything in his life worth saving. Tag to 5x02: Good God, Y'all! ....
1,116

Based on this prompt about Sam getting poisoned while he and
Dean are at odds. Dean is gone, and Castiel is the one to come to the
rescue. .... 1,293