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Comparing New Antihistamines
In chronic idiopathic urticaria, two studies found levocetirizine was superior to desloratadine for improving symptoms, and a single study found loratadine was superior to cetirizine (but there was no difference in quality of life). […] Of the newer antihistamines, cetirizine and levocetirizine are more sedating than loratadine and desloratadine, and possibly more sedating than fexofenadine.
allergy  science  medicine  drugs 
14 hours ago by mikael
Drug Class Review: Newer Antihistamines
Eleven short-term trials (1 good quality, 1 fair) showed no significant difference in comparisons of cetirizine to fexofenadine and loratadine, fexofenadine to loratadine and desloratadine, levocetirizine to loratadine, and azelastine nasal spray to desloratadine and olopatadine nasal spray.
science  allergy  medicine  drugs 
14 hours ago by mikael
Publication - The Unz Review - Oppenheimer - The Added Cubit
Robert Oppenheimer "The Added Cubit" -- on how much we have added to our knowledge, but how much wisdom and foresight has that gained us?
oppenheimer  philosophy  science  history  future  progress  society 
15 hours ago by tswaterman
A simple mechanism could have been decisive for the development of life | Hacker News
This is one in a number of papers exploring how biological phase separation/condensation may have provided favourable microenvironments for early life development.

For a nice primer on what biological phase separation is, see this (non-paywalled) general audience article from earlier this year in Nature (https://www.nature.com/articles/d41586-018-03070-2).

Some other work on phase separation as a means for primordial evolution and biochemistry includes a paper from Christine Keating in 2012 (WAY WAY ahead of the curve) [1], elegant work by Frank Jülicher [2], and more recently a nice paper from Keating and Phil Bevilacqua [3].

These papers (IMO) tie rather nicely into some theoretical predictions on self-organization from Jeremy England [4].

[1] Keating, C.D. (2012). Aqueous phase separation as a possible route to compartmentalization of biological molecules. Acc. Chem. Res. 45, 2114–2124.

[2] Zwicker, D., Seyboldt, R., Weber, C.A., Hyman, A.A., and Jülicher, F. (2016). Growth and division of active droplets provides a model for protocells. Nat. Phys. 13, 408.

[3] Poudyal, R.R., Pir Cakmak, F., Keating, C.D., and Bevilacqua, P.C. (2018). Physical Principles and Extant Biology Reveal Roles for RNA-Containing Membraneless Compartments in Origins of Life Chemistry. Biochemistry 57, 2509–2519.

[4] England, J.L. (2013). Statistical physics of self-replication. J. Chem. Phys. 139, 121923.

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mxwsn 1 day ago [-]

Phase separation really seems to be a hot topic in biology beyond early life development too, extending at least to the field of gene regulation.

A Phase Separation Model for Transcriptional Control. https://www.ncbi.nlm.nih.gov/pubmed/28340338

which already has 70 citations despite being published just 14 months ago.
science  chemistry  biology  physics  mathematics  to:Read  HN-comments  ****  exploration 
17 hours ago by MarcK
Engineering & Science Careers at Fresenius Medical Care
Our engineering and science professionals develop innovative products to help us provide the highest quality care.
Fresenius  science 
18 hours ago by TMP
八阕 ・ 广角新闻 ・ 科 教:【嫦娥二号揭秘美苏月球事件真相,细看后都沉默了】
据之前人们对NASA月球计划的了解,1972年阿波罗17号之后,美国就宣布停止了阿波罗计划。但是后来经过多方面的消息,证明了NASA对月球的研究并未停止,登月也在秘密的进行。
science  space 
18 hours ago by mathinker
Trump White House quietly cancels NASA research verifying greenhouse gas cuts | Science | AAAS
You can't manage what you don't measure. The adage is especially relevant for climate-warming greenhouse gases, which are crucial to manage—and challenging to measure. In recent years, though, satellite and aircraft instruments have begun monitoring carbon dioxide and methane remotely, and NASA's Carbon Monitoring System (CMS), a $10-million-a-year research line, has helped stitch together observations of sources and sinks into high-resolution models of the planet's flows of carbon. Now, President Donald Trump's administration has quietly killed the CMS, Science has learned.
2018-05  science  climate_change  environment  research  politics  evil  corruption  NASA 
20 hours ago by Weaverbird
Ripples in space-time or 3-pound bird? Ravens at Hanford foul test of Einstein’s theory | The Seattle Times
When Schofield and his colleagues investigated on a 100-plus-degree day, they found the pipes covered with peck marks, and even spotted one bird in the act of scraping its beak through the frost. “They peck for a while and make themselves a snow cone,” he said.
science  birds  corvidae 
20 hours ago by Weaverbird

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