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Russell Davies: Counting not connecting
I want a device that's smart but not connected. For counting.
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3 days ago by mayonissen
How to Your ROI (The Metrics that Matter) ~ 🗓💰📏 …
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25 days ago by sharonhh
Any particular gene has a specific location (its "locus") on a particular chromosome. For any two genes (or loci) alpha and beta, we can ask "What is the recombination frequency between them?" If the genes are on different chromosomes, the answer is 50% (independent assortment). If the two genes are on the same chromosome, the recombination frequency will be somewhere in the range from 0 to 50%. The "map unit" (1 cM) is the genetic map distance that corresponds to a recombination frequency of 1%. In large chromosomes, the cumulative map distance may be much greater than 50cM, but the maximum recombination frequency is 50%. Why? In large chromosomes, there is enough length to allow for multiple cross-overs, so we have to ask what result we expect for random multiple cross-overs.

1. How is it that random multiple cross-overs give the same result as independent assortment?

Figure 5.12 shows how the various double cross-over possibilities add up, resulting in gamete genotype percentages that are indistinguisable from independent assortment (50% parental type, 50% non-parental type). This is a very important figure. It provides the explanation for why genes that are far apart on a very large chromosome sort out in crosses just as if they were on separate chromosomes.

2. Is there a way to measure how close together two crossovers can occur involving the same two chromatids? That is, how could we measure whether there is spacial "interference"?

Figure 5.13 shows how a measurement of the gamete frequencies resulting from a "three point cross" can answer this question. If we would get a "lower than expected" occurrence of recombinant genotypes aCb and AcB, it would suggest that there is some hindrance to the two cross-overs occurring this close together. Crosses of this type in Drosophila have shown that, in this organism, double cross-overs do not occur at distances of less than about 10 cM between the two cross-over sites. ( Textbook, page 196. )

3. How does all of this lead to the "mapping function", the mathematical (graphical) relation between the observed recombination frequency (percent non-parental gametes) and the cumulative genetic distance in map units?

Figure 5.14 shows the result for the two extremes of "complete interference" and "no interference". The situation for real chromosomes in real organisms is somewhere between these extremes, such as the curve labelled "interference decreasing with distance".
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4 weeks ago by nhaliday

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