Ideas   83336

« earlier    

Got This Idea > About
Crowd building your idea. From Tyler Sondag.
ESB6  idea  ideamarket  Ideas  crowdsource  crowdsourcing 
yesterday by jeromekatz
Dispatches from the Real World: Time and Talents Community Centre
I really like reporting to stakeholders with a bunch of photos
communication  money  ideas  clever 
yesterday by gilest
What are the Laws of Biology?
The core finding of systems biology is that only a very small subset of possible network motifs is actually used and that these motifs recur in all kinds of different systems, from transcriptional to biochemical to neural networks. This is because only those arrangements of interactions effectively perform some useful operation, which underlies some necessary function at a cellular or organismal level. There are different arrangements for input summation, input comparison, integration over time, high-pass or low-pass filtering, negative auto-regulation, coincidence detection, periodic oscillation, bistability, rapid onset response, rapid offset response, turning a graded signal into a sharp pulse or boundary, and so on, and so on.

These are all familiar concepts and designs in engineering and computing, with well-known properties. In living organisms there is one other general property that the designs must satisfy: robustness. They have to work with noisy components, at a scale that’s highly susceptible to thermal noise and environmental perturbations. Of the subset of designs that perform some operation, only a much smaller subset will do it robustly enough to be useful in a living organism. That is, they can still perform their particular functions in the face of noisy or fluctuating inputs or variation in the number of components constituting the elements of the network itself.
scitariat  reflection  proposal  ideas  thinking  conceptual-vocab  lens  bio  complex-systems  selection  evolution  flux-stasis  network-structure  structure  composition-decomposition  IEEE  robust  signal-noise  perturbation  interdisciplinary  graphs  circuits  🌞  big-picture  hi-order-bits  nibble  synthesis 
3 days ago by nhaliday
What Does a “Normal” Human Genome Look Like? | Science
So, what have our first glimpses of variation in the genomes of generally healthy people taught us? First, balancing selection, the evolutionary process that favors genetic diversification rather than the fixation of a single “best” variant, appears to play a minor role outside the immune system. Local adaptation, which accounts for variation in traits such as pigmentation, dietary specialization, and susceptibility to particular pathogens is also a second-tier player. What is on the top tier? Increasingly, the answer appears to be mutations that are “deleterious” by biochemical or standard evolutionary criteria. These mutations, as has long been appreciated, overwhelmingly make up the most abundant form of nonneutral variation in all genomes. A model for human genetic individuality is emerging in which there actually is a “wild-type” human genome—one in which most genes exist in an evolutionarily optimized form. There just are no “wild-type” humans: We each fall short of this Platonic ideal in our own distinctive ways.
article  essay  org:nat  🌞  bio  biodet  genetics  genomics  mutation  genetic-load  QTL  evolution  sapiens  survey  summary  coding-theory  enhancement  signal-noise  egalitarianism-hierarchy  selection  tradeoffs  immune  recent-selection  perturbation  nibble  ideas 
4 days ago by nhaliday

« earlier    

related tags

-  10  640  absolute-relative  academia  accessibility  acquisition  actions  active-learning  activebranding  affiliate  also  america  arizona  art  article  articles  attentioneconomy  audio  austin  b2b  behavioral-gen  bestpractice  big-picture  bigidea  bio  biodet  bioinformatics  bits  blogideas  blueocean  books  brandingideas  burger  business-ideas  business-name  business  business_ideas  cabinet  canada  cartography  chemistry  circuits  cleaning  clever  coding-theory  color  come  communication  community  complex-systems  composition-decomposition  computer  concept  conceptual-vocab  constraint-satisfaction  content  cooking  cool  cosmology  cosplay  countdown  craft  creativity  crowdsource  crowdsourcing  customer  data  death  decor  delicious  density  design  differentiation  digital  discovery  discrete  discussion  discussions  disease  distribution  diy  documentary  domaineering  domains  earth  education  egalitarianism-hierarchy  einstein  electromag  embodied  enhancement  entrepreneurship  epidemiology  equilibrium  esb6  esri  essay  etsy  evolution  explanation  exposition  facebook  family  favs  filing  flux-stasis  food  ford  freelancing  frontend  fun  gaps  garage  gedanken  genetic-load  genetics  genomics  giants  gift  gifts  gis  goofy  graphs  great  hi-order-bits  history  holidays  home_improvement  how  humanities  humor  idea-generation  idea  ideamarket  ideas  ieee  ifttt  imagery  immune  information-theory  innovation  inspiration  inspiring  instapaper  instruction  interdisciplinary  interesting  invariance  jm  kitchen  lattice  launch:  learning  leesmolin  lens  libguides  librarianship  list  long-short-run  lust  make  manufacturing  maps  marketing  marketing_strategy  math  maxim-gun  medicine  medicinemaking  medium  microsoft  ml  moments  money  mostly-modern  movies  moz  multi  music  mutation  myself  name-generator  name  names  nasa  nature  network-structure  news  nibble  nihil  novel  now  oldskool  order-disorder  org:edu  org:inst  org:junk  org:mag  org:nat  org:sci  organization  paradox  parasites-microbiome  parker  paternal-age  patty  peace_lily  perturbation  photoshop  physics  placeholder  plants  pocket  policy  politics  polyamory  popsci  population  potential  pre-ww2  product  production  project  proposal  psychology  public-health  qtl  questions  quotes  recent-selection  recommend  recommended  red-queen  reference  reflection  relationshipanarchy  relationships  relativity  rental  research  robots  robust  rs  s3  saappaadu  sam  sanctity-degradation  sapiens  scale  science  scitariat  selection  seo  sequencer  shopping  side  side_projects  signal-noise  smart  socialmedia  socialnetwork  sockets  speculation  spreading  startup-ideas  startup  startups  stocking...  storage  story  structure  study  summary  survey  sustainability  svg  sydney  symmetry  synthesis  tactics  takeaway  tcstariat  teacher  teaching  ted  temporary  testing  that  the-trenches  the_kuang  thingstodo  thinking  thought  tips  to  tools  trabajo  tradeoffs  travel  trivia  trust  ua  uanews  unintended-consequences  up  useful  visuo  voting  want  web-design  web  webdev  west-hunter  wiki  with  woodworking  work  yc  ycombinator  yum  zuckerburg    🌞 

Copy this bookmark: