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Goldman Sachs Asks: ‘Is Curing Patients A Sustainable Business Model?’ | Above the Law
In April, reports surfaced that analysts from Goldman Sachs asked, “Is curing patients a sustainable business model?” This is a terrible question for so many reasons, but as I detail further below, this question reveals that many companies really have only one goal and how inadequate our current patent system is in incentivizing public goods.

Goldman Sachs basically concluded that, from a business perspective, curing patients will result in less revenue compared to ongoing, chronic treatments. Using pharmaceutical company Gilead’s treatment for hepatitis C as an example, Goldman Sachs noted that sales for the treatment peaked at $12.5 billion in 2015, but have been declining since then and is projected at less than $4 billion for 2018. The reason, of course, is that a successful cure “exhaust[s] the available pool of treatable patients” and therefore “could represent a challenge for genome medicine developers looking for sustained cash flow.” The analyst went on to note that curing an infectious disease “also decreases the number of carriers able to transmit the virus to new patients, thus the incident pool also declines,” further leading to a decreased need for the treatment.
pharmacy  medical  cure  disease  profit 
21 days ago by Quercki
How an Alzheimer’s ‘cabal’ thwarted progress toward a cure - STAT
This stifling of competing ideas, say a growing number of scholars, is a big reason why there is no treatment for Alzheimer’s.
Alzheimer  Cure 
7 weeks ago by FredericJacobs
The FDA is fast-tracking a second psilocybin drug to treat depression | Popular Science
In October 2018 the FDA granted a Breakthrough Therapy designation to COMPASS Pathways for its use of psilocybin in addressing treatment-resistant depression (TRD). As the name suggests, this condition is defined by depressive symptoms that don’t improve with the use of two or more standard therapies. Also, in March 2019, the FDA approved a TRD nasal spray (designed to mimic the positive effects of the hallucinogenic ketamine) as the first new antidepressant in decades.

But unlike that recently released spray and COMPASS Pathways’ ongoing trials, the latest potential therapy to get a boost from the FDA targets major depressive disorder (MDD). While TRD is estimated to affect about 5 million people in the U.S., at least 17 million American adults have MDD, which is more commonly referred to simply as “depression.” Depression is the leading cause of disability among Americans age 15 to 44, and affects hundreds of millions of people globally.

The latest Breakthrough Therapy designation goes to the Usona Institute, a nonprofit medical research group dedicated to “understanding of the therapeutic effects of psilocybin and other consciousness-expanding medicines.” Usona recently launched a Phase 2 clinical trial (more on what trial phases mean here) and is actively recruiting participants for an 80-person study. The trial will aim to determine the efficacy of treating depressed patients with single, one-time oral doses of psilocybin."
depression  cure  treatment  mushrooms 
12 weeks ago by dandv
82-Year-Old Woman With Dementia Gets Her Memory Back After Changing Her Diet – Collective Evolution
IOW she starting eating #paleo! Amazing example of #food’s ability to #cure #dementia #alzheimer
dementia  alzheimer  casestudy  example  paleo  food  cure  wellness  health  nutrition 
october 2019 by csrollyson
This med student was given last rites before finding a treatment that saved his life. His method could help millions - CNN
After David Fajgenbaum suffered repeated life-threatening relapses of Castleman disease, he became laser-focused on trying to save his own life. Against the odds he pioneered a new treatment and an approach to drug research that could help others with rare diseases.
medicine  disease  genius  cure  research 
september 2019 by dartagan
Scientists attempt to cure HIV using CRISPR, with varying results
https://www.nejm.org/doi/10.1056/NEJMoa1817426

In 2017, Deng and team engineered human stem cells that mimicked a rare form of natural immunity to HIV and administered them to an HIV-infected man who already needed a blood stem cell transplant to treat cancer.

The man was treated with chemicals and radiation to wipe out his bone marrow and make room for the millions of engineered stem cells that were then transplanted. These new donated stem cells would replace the patient’s unhealthy ones in an attempt to cure his cancer.

the donated stem cells had been edited with CRISPR to cripple the CCR5 gene, which is needed for HIV to enter immune cells.

Now, more than two years later, the patient is still in good health and his cancer is in full remission.

After the transplant, only 5 to 8% of the bone marrow cells carried a copy of the CCR5 edit, meaning they were significantly outnumbered by cells that are susceptible to infection.

“They need to approach 90% or more, I think, to actually have a chance of curing HIV,” says June.
CRISPR  cure  HIV  bone  marrow  transplant  cancer  genetic  engineering 
september 2019 by dandv
Rohani Ilaj aur Istikhara Ep 830 | روحانی علاج اور استخارہ | Islamic Spiritual Treatment
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august 2019 by snapeplus
Student Sylvie Sturm Critiques San Francisco Media Coverage of Homelessness
SAN FRANCISCO PUBLIC PRESS -- Sylvie Sturm is a journalist and a recent graduate of San Francisco State University. For a research project, she compiled and analyzed hundreds of articles and columns published in the San Francisco Bay Area about homelessness, starting with the 2016 effort led by the San Francisco Chronicle to create an annual media blitz, the SF Homeless Project. Sturm coded each article for its framing and focus, and also interviewed reporters, advocates, government officials and editors about how media cover homelessness. She then created a video summary of her findings.

“We all know that politics is partially about votes and about the perception of the politician doing well and the city doing well,” Sturm said. “And that's not to say that the government isn’t working very, very hard to do what it can to solve this problem and to help people who are unhoused. But to take everything that they say at their word? I mean, we are reporters, we are journalists; we should do a little bit of legwork.”
jour  student  undergraduate  alumni  research  regional  metrics  cure 
august 2019 by sfstatelca
What is the Best Way to Cure High Blood Pressure Permanently?
The Most Fun Way to Cure High Blood Pressure Permanently; Is it Possible to
Cure  High  Blood  Pressure  Permanently  Without  Medications? 
july 2019 by luv2sex.info
What is the best way to completely reverse type-2 diabetes?
What is the best way to completely reverse type-2 diabetes? Read on to
learn  this  all-natural  way  using  3  simple  steps  to  cure  diabetes 
july 2019 by luv2sex.info

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