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Survival in Patients With Melanoma With Active Brain Metastases Treated With Pembrolizumab | PracticeUpdate
This study presents long-term follow-up of pembrolizumab-treated patients with new or progressing brain metastases treated in a phase II clinical trial. The 23 patients had one or more asymptomatic, untreated 5- to 20-mm brain metastasis not requiring corticosteroids. Pembrolizumab was active in melanoma brain metastases. The toxicity profile was acceptable, and durable responses were observed. At 2 years, survival was comparable to that of patients without brain metastases treated with anti–PD-1 agents.

Current evidence supports use of pembrolizumab in the treatment of small, asymptomatic brain metastases.
cancer  immunotherapy  brain 
2 days ago by cnk
Minimally Invasive vs Abdominal Radical Hysterectomy for Cervical Cancer | PracticeUpdate
Minimally invasive surgery for early-stage cervical cancer had emerged as the standard of care in spite of the fact that no prospective studies were conducted that confirmed noninferior oncologic outcomes compared with open surgery. The move toward minimally invasive hysterectomies followed a trend seen in other malignancies, such as colorectal and prostate cancers, where trials had demonstrated equal oncologic outcomes with open and laparoscopic techniques. In the study by Ramirez et al, disease-free survival (DFS) at 4.5 years was 86% with minimal invasive surgery vs 96.5% with open surgery, and the overall survival (OS) at 3 years was 93.8% vs 99%.

The observed detriment in DFS and OS associated with minimally invasive surgery of early-stage cervical cancer is not easy to explain and has sent shock waves through the field of gynecological oncology. It is unclear if the routine use of an uterine manipulator or the insufflation of CO2 gas might have contributed to local tumor cell contamination and be responsible for the higher recurrence rate. The difference in survival observed in a randomized setting, which was confirmed in an observational cohort study, highlights that the appropriate management of early-stage cervical cancer has to be discussed cautiously with each patient. However, selected patient groups with tumors less than 2 cm and without additional risk factors may still benefit from minimally invasive surgery.
2 days ago by cnk
甲状腺髓样癌  mtc  health  thyroid  cancer 
4 days ago by dlutcat
新一代RET抑制剂的头对头较量:BLU-667 vs LOXO-292_新浪医药新闻
作者:禾木 PharmcubeRET(rearranged during transfection)是一个原癌基因,位于10号染色体。RET
RET  MTC  cancer  thyroid 
4 days ago by dlutcat
Today I received my scan results, which show a complete metabolic response. In other words, MY CANCER IS GO…
cancer  from twitter_favs
4 days ago by parsingphase
Rainforest vine compound starves pancreatic cancer cells
The researchers found that this new compound killed pancreatic cancer cells under conditions of nutrient starvation but not when nutrients were plentiful. Ancistrolikokine E3 also inhibited cancer cell migration and colonization in lab tests, which suggests that the compound could help prevent metastasis in patients.
science  medicine  cancer 
4 days ago by emkay
The Link Between Diet Quality and CRC Outcomes | Cancer Network
Badly written but I think the gist is that it is worth changing your diet after a non-metastatic colorectal cancer diagnosis as it will improve survival even if your diet before then was crappy.

“Consistently observed inverse associations suggest that prognosis may improve with better post-diagnosis diet, even when prediagnosis diet quality was relatively low,” the researchers wrote. “These results were supported further in postdiagnostic models that identified statistically significant associations between diet quality and mortality that were independent of prediagnosis diet quality.”

Based on these results, the researchers wrote that recommendations should be made in support of high diet quality before and after colorectal cancer diagnosis to improve survival.

“Collectively, the results from all dietary patterns suggest that consumption of a diet high in plant products and fiber while limiting red and processed meat and added sugars both before and after diagnosis may be beneficial,” the researchers wrote.
cancer  diet 
5 days ago by cnk
13-year-old Rishab Jain won the 2018 Discovery Education 3M Young Scientist Challenge for making a tool to help treat pancreatic cancer more safely. His ambitious work is an inspiration to all.
cancer  research  medicine  ai 
5 days ago by bradbarrish
Impact of diet on prostate cancer: a review | Prostate Cancer and Prostatic Diseases
dietary fat and prostate cancer
looks to me like the correlation studies in humans are inconclusive
prostate  cancer  fat 
5 days ago by brentfarwick
Pancreatic cancer’s addiction could be its end
Cold Spring Harbor, NY — Cancer cells are often described as cells “gone bad” or “renegade.” New research reveals that in some of the deadliest cases of pancreatic cancer, these rebellious cells have an unexpected addiction. Now, scientists are investigating if that addiction can be used to bring about a tumor’s end. Cold Spring Harbor...
cancer  research 
5 days ago by bradbarrish
Jury delivers $25.5 million 'statement' to Aetna to change its ways - CNN
(CNN)An Oklahoma jury has awarded $25.5 million to the family of a cancer patient denied coverage by Aetna, with jurors saying that the insurer acted "recklessly" and that the verdict was meant as a message for Aetna to change its ways.
The award is believed to be the largest verdict in an individual "bad faith" insurance case in Oklahoma history, one court observer said, and could have major ramifications across the country for a form of cancer treatment called proton beam therapy.
The case revolved around the 2014 denial of coverage for Orrana Cunningham, who had stage 4 nasopharyngeal cancer near her brain stem. Her doctors wanted her to receive proton beam therapy, a targeted form of radiation that could pinpoint her tumor without the potential for blindness or other side effects of standard radiation.
Aetna denied her coverage, calling the therapy investigational and experimental.
health  insurance  legal  business  money  cancer 
6 days ago by rgl7194

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