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Accurate Genomic Prediction Of Human Height | bioRxiv
Stephen Hsu's compressed sensing application paper

We construct genomic predictors for heritable and extremely complex human quantitative traits (height, heel bone density, and educational attainment) using modern methods in high dimensional statistics (i.e., machine learning). Replication tests show that these predictors capture, respectively, ~40, 20, and 9 percent of total variance for the three traits. For example, predicted heights correlate ~0.65 with actual height; actual heights of most individuals in validation samples are within a few cm of the prediction.
study  bio  preprint  GWAS  state-of-art  embodied  genetics  genomics  compressed-sensing  high-dimension  machine-learning  missing-heritability  hsu  scitariat  education  🌞  frontier  britain  regression  data  visualization  correlation  phase-transition  multi  commentary  summary 
4 days ago by nhaliday
Global determinants of navigation ability | bioRxiv
Using a mobile-based virtual reality navigation task, we measured spatial navigation ability in more than 2.5 million people globally. Using a clustering approach, we find that navigation ability is not smoothly distributed globally but clustered into five distinct yet geographically related groups of countries. Furthermore, the economic wealth of a nation (Gross Domestic Product per capita) was predictive of the average navigation ability of its inhabitants and gender inequality (Gender Gap Index) was predictive of the size of performance difference between males and females.

- Figure 1 has the meat
- gender gap larger in richer/better-performing countries
- Anglo and Nordic countries do best (Finnish supremacy wins the day again)
- surprised China doesn't do better, probably a matter of development
- Singapore is close behind the Anglo-Nords tho
- speculation that practice of orienteering (originally Swedish) may be related to Nords doing well
- somewhat weird pattern wrt age
study  bio  preprint  psychology  cog-psych  iq  psychometrics  spatial  navigation  pop-diff  gender  gender-diff  egalitarianism-hierarchy  correlation  wealth  wealth-of-nations  econ-metrics  data  visualization  maps  world  developing-world  marginal  europe  the-great-west-whale  nordic  britain  anglo  usa  anglosphere  china  asia  sinosphere  polis  demographics  age-generation  aging  EU  group-level  regional-scatter-plots  games  simulation 
8 days ago by nhaliday
Plastic kills – let's stop treating it like a normal part of modern life
The oceans are now so full of man-made detritus that our health is being put at risk too. About a third of fish caught off the coast of the UK now contain traces of plastic. Some plastics contain diethylhexyl phthalate, which is toxic and thought to be carcinogenic. When you bear in mind that British seafood eaters may ingest more than 10,000 pieces of plastic each year, it’s obvious that plastic has been a complete disaster for health.
seafood  fish  oceans  Plastic  Plastik  carcinogen  carcinogenic  heavy  metals  water  pollution  public  health  Cancer  WHO  crisis  environment  ecological  disaster  bio  diversity 
11 days ago by asterisk2a
Of Mice and Men | West Hunter
It’s not always easy figuring out how a pathogen causes disease. There is an example in mice for which the solution was very difficult, so difficult that we would probably have failed to discover the cause of a similarly obscure infectious disease in humans.

Mycoplasma pulmonis causes a chronic obstructive lung disease in mice, but it wasn’t easy to show this. The disease was first described in 1915, and by 1940, people began to suspect Mycoplasma pulmonis might be the cause. But then again, maybe not. It was often found in mice that seemed healthy. Pure cultures of this organism did not consistently produce lung disease – which means that it didn’t satisfy Koch’s postulates, in particular postulate 1 (The microorganism must be found in abundance in all organisms suffering from the disease, but should not be found in healthy organisms.) and postulate 3 (The cultured microorganism should cause disease when introduced into a healthy organism.).

Well, those postulates are not logic itself, but rather a useful heuristic. Koch knew that, even if lots of other people don’t.


Here’s how they solved it. You can raise germ-free mice. In the early 1970s, researchers injected various candidate pathogens into different groups of germ-free mice and waited to see which, if any, developed this chronic lung disease. It was Mycoplasma pulmonis , all right, but it had taken 60 years to find out.

It turned out that susceptibility differed between different mouse strains – genetic susceptibility was important. Co-infection with other pathogens affected the course of the disease. Microenvironmental details mattered – mainly ammonia in cages where the bedding wasn’t changed often enough. But it didn’t happen without that mycoplasma, which was a key causal link, something every engineer understands but many MDs don’t.

If there was a similarly obscure infectious disease of humans, say one that involved a fairly common bug found in both the just and the unjust, one that took decades for symptoms to manifest – would we have solved it? Probably not.

Cooties are everywhere.

gay germ search:
It’s hard to say, depends on how complicated the path of causation is. Assuming that I’m even right, of course. Some good autopsy studies might be fruitful – you’d look for microanatomical brain differences, as with nartcolepsy. Differences in gene expression, maybe. You could look for a pathogen – using the digital version of RDA (representational difference analysis), say on discordant twins. Do some old-fashioned epidemiology. Look for marker antibodies, signs of some sort of immunological event.

Do all of the above on gay rams – lots easier to get started, much less whining from those being vivisected.

Patrick Moore found the virus causing Kaposi’s sarcoma without any funding at all. I’m sure Peter Thiel could afford a serious try.
west-hunter  scitariat  discussion  ideas  reflection  analogy  model-organism  bio  disease  parasites-microbiome  medicine  epidemiology  heuristic  thick-thin  stories  experiment  track-record  intricacy  gotchas  low-hanging  🌞  patience  complex-systems  meta:medicine  multi  poast  methodology  red-queen  brain-scan  neuro  twin-study  immune  nature  gender  sex  sexuality  thiel  barons  gwern 
17 days ago by nhaliday
野蛮生长 - 我的又一个五年 - 十五言
bio  phd  story  writing  life  programming  history  hobby 
20 days ago by aries1988
Mechanisms of microbial traversal of the blood–brain barrier
A journey into the brain: insight into how bacterial pathogens cross blood–brain barriers:
How do extracellular pathogens cross the blood-brain barrier?:
Defense at the border: the blood–brain barrier versus bacterial foreigners:
study  bio  medicine  health  embodied  neuro  neuro-nitgrit  disease  parasites-microbiome  metabolic  🌞  pdf  piracy  org:nat  multi  red-queen  epidemiology 
22 days ago by nhaliday

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