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Razer Phone 2 Is Coming: Here’s Our List of Demands
The Razer Phone launched to great aplomb when it was unveiled in 2017. Effectively creating a new class of smartphones, the Razer Phone combined top-edge specifications with purpose-built features aimed at its core market of gamers. Soon enough, we’ve seen the ASUS ROG Phone, Xiaomi Black Shark, and Honor Play flood into the market, early...

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Razer  Phone  2  Is  Coming:  Here’s  Our  List  of  Demands 
6 days ago by vrzone
Glycemic control and vascular complications in type 2 diabetes mellitus - UpToDate
[tl;dr: Glycemic control improves microvascular outcomes in type 2 diabetes, including progression of nephropathy, manifestation and progression of retinopathy, and retinal photocoagulation; and showed a beneficial effect of intensive therapy on the development of more advanced clinical outcomes in renal disease and its precursors in the one study with long-enough follow up to assess effect. Cardiovascular risk benefit "has not been established as clearly" for type 2 as for type 1.]

Although the role of glycemic control on microvascular disease in type 2 diabetes was documented in the United Kingdom Prospective Diabetes Study (UKPDS), its role in reducing cardiovascular risk has not been established as clearly for type 2 diabetes....

improving glycemic control improves microvascular outcomes, as illustrated by the findings of a meta-analysis of randomized trials (34,912 participants) [5]. There was a reduction in the risk of microvascular complications (a composite outcome including progression of nephropathy, manifestation and progression of retinopathy, and retinal photocoagulation) in the intensive compared with standard glycemic control group (relative risk [RR] 0.88, 95% CI 0.82-0.95). There were significant reductions in risk for each of the individual components.

In other meta-analyses of trials (over 28,000 adults) evaluating the benefits of intensive versus conventional glycemic control specifically on renal outcomes, there was a statistically significant reduction in the risk of microalbuminuria and macroalbuminuria in patients randomly assigned to intensive glycemic control (risk ratios of 0.86 and 0.74, respectively) [6,7]. The reduction in risk of end-stage renal disease did not reach statistical significance (RR 0.69, 95% CI 0.46-1.05). There was no reduction in the risk of doubling of the serum creatinine level or death from renal disease (RRs 1.06 and 0.99, respectively) [6]. Of note, the majority of the trials in the meta-analyses were not of long enough duration to show a beneficial effect of glycemic control on end-stage renal disease, which typically manifests after 10 to 20 years of diabetes duration [8]. In the trials included in the meta-analyses, the absolute rates of severe renal outcomes were low in both the intensive- and conventional-therapy groups, reducing the ability of the analysis to demonstrate a benefit, if one exists. In the one trial with longer-term follow-up (United Kingdom Prospective Diabetes Study [UKPDS] cohort followed for 22 years), there was a beneficial effect of intensive therapy on the development of more advanced clinical outcomes, including renal disease
type  2  T2D  diabetes  risk  tight  management  glucose  control  blood  benefit  morbidity  mortality  microvascular  complications  kidneys  eyes  retinopathy  nephropathy  renal  disease  cardiovascular  peer-reviewed  research  review  meta-analysis  overview  in  vivo  situ  human  clinical  trial  symptoms  comorbidities  self  treatment  care 
8 days ago by Michael.Massing
Devlet üniversitelerinde 80 bölüm sıfır çekti
via Pocket - Devlet üniversitelerinde 80 bölüm sıfır çekti - Added September 01, 2018 at 06:02AM
IFTTT  Pocket  2  min 
8 days ago by kutsal
The Broken Promise of Android Treble – BirchTree
via Pocket - The Broken Promise of Android Treble - Added September 03, 2018 at 01:11AM
IFTTT  Pocket  \'  okundu  2  min  feedly 
8 days ago by kutsal
2012 MacBook Air Modelleri Klasik Ürünler Listesine Giriyor! - Sihirli Elma
via Pocket - 2012 MacBook Air Modelleri Klasik Ürünler Listesine Giriyor! - Added August 30, 2018 at 02:55AM
IFTTT  Pocket  \'  okundu  2  min  feedly  toplubak 
8 days ago by kutsal
Vina Lustado’s home-office using 2 tiny houses in “L” + deck – *faircompanies
via Pocket - Vina Lustado’s home-office using 2 tiny houses in “L” + deck - Added August 30, 2018 at 02:38AM
IFTTT  Pocket  \'  okundu  2  min  feedly  tiny  living 
8 days ago by kutsal
Albayrak'ın kurduğu vakfın okullarında ders: 'Yeşil katliamı' - Cumhuriyet Çevre Haberleri
via Pocket - Albayrak'ın kurduğu vakfın okullarında ders: 'Yeşil katliamı' - Added September 09, 2018 at 06:34PM
IFTTT  Pocket  2  min  şehir 
8 days ago by kutsal

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