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This is why we can't have nice things.
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10 days ago by jtyost2
Twitter
Excuse my language, but the level of dipshit you have to be to speak like this to Meg Linehan is unfathomable.

I w…
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10 days ago by dannypage
ICOs are increasingly just for venture capitalists
A look at the trend of crypto projects running private sale ICOs for accredited and strategic investors only, excluding ordinary retail investors
10 days ago by joeo10
Twitter
Some drama remains in NY about the line; the party had endorsed Nixon and Williams, and backed a placeholder…
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10 days ago by girma
Bound by Friendship by Cinaed
Mablung walked in search of Túrin, for where the king’s ward was, Beleg was certain to be.

(Or two times Mablung was troubled by Beleg and Túrin's friendship.)
beleg  mablung  turin  2K  gen 
10 days ago by elftrash
He Just Makes Fuck-Ups - Chapter 1 - impertinence - Deadpool (Movieverse) [Archive of Our Own]
Domino is in a tax-related jam. Wade and Cable get married and neither of them remember it.
Lucky Domino. Unlucky love-sick Cable.
fic  10k-50k  marvel  marriage_of_convenience  cable/deadpool 
10 days ago by reallyawesomecostumes
Twitter
And keep your "It might have been an accident" or other backbreaking attempts to explain this away when you know if…
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10 days ago by joshd
Twitter
According to our input to this point, the business need is orchestrating process steps across different sys…
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10 days ago by aqualung
Twitter
Somewhat amused that the structure of Docker makes it unreasonably difficult to build Docker images inside Docker c…
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10 days ago by aslakr
A Constellation Anyone Could Read by Cinaed
One winter's night in Doriath, a celebration and a starlit sky reveal a few truths.
beleg/turin  2K 
10 days ago by elftrash
Twitter
When the Fourth Industrial Revolution Goes Bad: A Cautionary Tale

cc
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10 days ago by mellowfish
Twitter
When the Fourth Industrial Revolution Goes Bad: A Cautionary Tale

cc
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10 days ago by briantrice
Twitter
RT : My all-time favourite example of survivorship bias
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10 days ago by noahsussman
Twitter
Cannot wait! Can’t recommend Ted Chiang highly enough
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10 days ago by timoni
U.S. Silently Enters New Age of Cyberwarfare
The quiet removal of PPD-20, an Obama-era policy limiting use of destructive offensive cyberweapons, signals a watershed moment for how the US engages in cyberwarfare
10 days ago by joeo10
Twitter
Incredible visualisation. Hits close to home too coz of Kerala floods.
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10 days ago by vishnugopal
Twitter
RT : When nothing else will justify the senseless death of a citizen at the hands of a wayward police officer, quick, re…
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10 days ago by divigation
Twitter
And to cut off the "Yeah but" bullshit- yes, I know it was New York's primary, not the actual midterms. Don't care.…
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10 days ago by joshd
(404) https://workflow.is/workflows/5B0D4D426C474Ef9Aefb10536561963F
I 📱 Wrote 📱 a 📱 Workflow/Siri-Shortcut 📱 to 📱 Make 📱 Clap 📱 Tweets 📱
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10 days ago by kiodane
Twitter
For a long time I was thinking no, I don't want land. But now...
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10 days ago by avesse
Twitter
I have been doing a lot of thinking at work and I will need to go home and do a lot of thinking and generating word…
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10 days ago by stealingsand
Twitter
“I got the 18 ram or whatever” - That feeling when gets an iMac Pro and tries to play it off as no bi…
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10 days ago by penllawen
Twitter
Notice how these are also the building blocks of a healthy, safe, prosperous society in general. Notice how they ar…
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10 days ago by stinkingpig
Glycemic control and vascular complications in type 2 diabetes mellitus - UpToDate
[tl;dr: Glycemic control improves microvascular outcomes in type 2 diabetes, including progression of nephropathy, manifestation and progression of retinopathy, and retinal photocoagulation; and showed a beneficial effect of intensive therapy on the development of more advanced clinical outcomes in renal disease and its precursors in the one study with long-enough follow up to assess effect. Cardiovascular risk benefit "has not been established as clearly" for type 2 as for type 1.]

Although the role of glycemic control on microvascular disease in type 2 diabetes was documented in the United Kingdom Prospective Diabetes Study (UKPDS), its role in reducing cardiovascular risk has not been established as clearly for type 2 diabetes....

improving glycemic control improves microvascular outcomes, as illustrated by the findings of a meta-analysis of randomized trials (34,912 participants) [5]. There was a reduction in the risk of microvascular complications (a composite outcome including progression of nephropathy, manifestation and progression of retinopathy, and retinal photocoagulation) in the intensive compared with standard glycemic control group (relative risk [RR] 0.88, 95% CI 0.82-0.95). There were significant reductions in risk for each of the individual components.

In other meta-analyses of trials (over 28,000 adults) evaluating the benefits of intensive versus conventional glycemic control specifically on renal outcomes, there was a statistically significant reduction in the risk of microalbuminuria and macroalbuminuria in patients randomly assigned to intensive glycemic control (risk ratios of 0.86 and 0.74, respectively) [6,7]. The reduction in risk of end-stage renal disease did not reach statistical significance (RR 0.69, 95% CI 0.46-1.05). There was no reduction in the risk of doubling of the serum creatinine level or death from renal disease (RRs 1.06 and 0.99, respectively) [6]. Of note, the majority of the trials in the meta-analyses were not of long enough duration to show a beneficial effect of glycemic control on end-stage renal disease, which typically manifests after 10 to 20 years of diabetes duration [8]. In the trials included in the meta-analyses, the absolute rates of severe renal outcomes were low in both the intensive- and conventional-therapy groups, reducing the ability of the analysis to demonstrate a benefit, if one exists. In the one trial with longer-term follow-up (United Kingdom Prospective Diabetes Study [UKPDS] cohort followed for 22 years), there was a beneficial effect of intensive therapy on the development of more advanced clinical outcomes, including renal disease
type  2  T2D  diabetes  risk  tight  management  glucose  control  blood  benefit  morbidity  mortality  microvascular  complications  kidneys  eyes  retinopathy  nephropathy  renal  disease  cardiovascular  peer-reviewed  research  review  meta-analysis  overview  in  vivo  situ  human  clinical  trial  symptoms  comorbidities  self  treatment  care 
10 days ago by Michael.Massing
From Sweet Fellowship Comes Nectar - Laura JV (jacquez) - The Lord of the Rings - All Media Types [Archive of Our Own]
Gimli and Legolas negotiate the borders of their bodies and their hearts, aided by affection, impeded by their own understanding.
fic  10k-50k  lotr  legolas/gimli  gender 
10 days ago by reallyawesomecostumes
Blood, Song, and Silver by theotherwesley
Celebrimbor, lord of Eregion, ignores the advice of his peers and welcomes a stranger into his city who promises to teach him techniques in smithing that will grant power over time and entropy. He learns many things from his new teacher that he was not prepared for.

The rest is history: Beware of Maiar bearing gifts.
celebrimbor/sauron  10-15K 
10 days ago by elftrash
Twitter
RT : SINNERS IN THE HANDS OF AN ANGRY MOD
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10 days ago by brchastain
Erik | Applebee's Grill + Bar
I'm at Applebee's Grill + Bar in Bellevue, WA
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10 days ago by ethauvin
Twitter
RT : what if, instead, every year we made him pay a large portion his $163 billion wealth and distributed it to existing…
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10 days ago by burritojustice
Twitter
We seek to San Franciscize the city. To make San Francisco more like itself by making space for more of us
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10 days ago by kevinriggle-twitter
Twitter
there were a few nice things left in the world and not having to fly through Seattle or Vancouver to get to Victori…
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10 days ago by burritojustice
U.S. Mobile Giants Want to be Your Online Identity
Four major US carriers detail “Project Verify” for letting web sites authenticate users via data unique to a customer's phone and mobile subscriber account
10 days ago by joeo10
Twitter
Letting out a laugh, 39-year-old Olimpia Godoy looked at the walls of her mobile home.

“This is just cardboard,” s…
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10 days ago by andriak
Nvidia Announces Tesla T4 GPUs With Turing Architecture
Nvidia announces the Tesla T4 for faster AI inference in data centers, says it offers up to 12x the performance of previous-gen within the same power envelope
10 days ago by joeo10
Twitter
RT : Let me better explain this to you.

Hours after a stranger shot IN HIS APARTMENT, police got a search…
BothamJean  from twitter_favs
10 days ago by ali.alkhatib
Twitter
RT : As I said when I first saw this lovely woman, this is what music does. So joyful. I also love how she noticed Missy…
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10 days ago by divigation
[Official] Animal Crossing Coming to Switch in 2019! : NintendoSwitch
[Official] Animal Crossing Coming to Switch in 2019! via /r/NintendoSwitch
IFTTT  Reddit 
10 days ago by jdoecrow
I’ve been cleaning the wrong way my entire life. : BeAmazed
I’ve been cleaning the wrong way my entire life. via /r/BeAmazed
IFTTT  Reddit 
10 days ago by jdoecrow
The Last Gif You'll Ever Need : Eyebleach
The Last Gif You'll Ever Need via /r/Eyebleach
IFTTT  Reddit 
10 days ago by jdoecrow
Puppy falls asleep mid lick!! : StoppedWorking
Puppy falls asleep mid lick!! via /r/StoppedWorking
IFTTT  Reddit 
10 days ago by jdoecrow
Omg our college president looks like Voldemort lol he was giving a presentation and I wanted to yell the dark lord reigns again. Lol : harrypotter
Omg our college president looks like Voldemort lol he was giving a presentation and I wanted to yell the dark lord reigns again. Lol via /r/harrypotter
IFTTT  Reddit 
10 days ago by jdoecrow
Apple Bows to the Chinese Market Again With Latest IPhones
Apple iPhone Xs models do not include eSIM tech in China, since carriers there stopped offering cellular service to eSIM-based Apple Watch models in 2017
10 days ago by joeo10
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