recent bookmarks

Be Better at Parties - Smarter living Guides - The New York Times
People love to party! Well, at least some of them do. For the rest of us, parties bring on waves of feelings, good and bad, much like the events themselves. Here's everything you've ever wanted to know about being the hit of the party.
10 days ago by creditcardnumber
Twitter
"You can blow out a candle
But you can't blow out a fire"
from twitter_favs
10 days ago by andriak
Twitter
I just bumped into an old hostel resident who I got rehoused and she hugged me in the street. It was one of those v…
from twitter_favs
10 days ago by adamamyl
Twitter
VCU Libraries will close at midnight today, Wednesday, Sept. 12 and will remain closed in alignment with the univer…
from twitter_favs
10 days ago by streetlamp
Twitter
Thanks for a great interview and sharing my story! That interview was a lot of fun.
from twitter_favs
10 days ago by jerrythepunkrat
Twitter
There was no "trying to flee", there was calmly walking to the potluck. The…
from twitter_favs
10 days ago by andriak
Twitter
We can only hope MP Watson gets more educated about etiology and fruit before the campaign rolls out. And I hope ag…
from twitter_favs
10 days ago by Michael.Massing
Twitter
Here is a controversy that is tailor made for the president, who will forget there is a giant hurricane hitting the…
from twitter_favs
10 days ago by AramZS
Twitter
Non-sense! The quality of an analysis cannot be reduced to t…
from twitter_favs
10 days ago by hwileniu
Twitter
Discovering ur trans: I'm not the only person like me in the world
Discovering the trans community: look at all the…
from twitter_favs
10 days ago by new299
Twitter
Discovering ur trans: I'm not the only person like me in the world
Discovering the trans community: look at all the…
from twitter_favs
10 days ago by quicksilvre
Twitter
Discovering ur trans: I'm not the only person like me in the world
Discovering the trans community: look at all the…
from twitter_favs
10 days ago by enne
Twitter
あ、これいいかもw((いまだに新聞買ってるのは生ゴミ処理用ってのが大きいので)。
. さんの「「新聞はとりたくないけど掃除や梱包用に新聞紙を使いたい!」という需要に答える「印刷前の新聞紙」が発売中」…
from twitter
10 days ago by minoguchi
Predicting Tumor Progression in CRC Patients | Cancer Network
Combining regular liquid plasma biopsies using plasma cell-free DNA (cfDNA) and solid-tissue biopsies with a mathematical modeling of tumor evolution helped anticipate tumor progression in patients with metastatic colorectal cancer, according to the results of a phase II study published in Cancer Discovery.


These methods could inform clinicians about the “timing of clinical decisions and future treatment strategies,” according to researchers led by Nicola Valeri, MD, PhD, team leader in gastrointestinal cancer biology and genomics at the Institute of Cancer Research, London, and consultant medical oncologist at the Royal Marsden NHS Foundation Trust.

According to the study, although clinicians often use tumor biopsies for cancer genotyping, many tumors have intratumor heterogeneity that can drive treatment resistance. Therefore, multiple biopsies in time and space could help provide a better understanding on how tumors evolve to resist therapy.

Valeri and colleagues analyzed the results of the PROSPECT-C trial, a study looking at biomarkers of response and resistance to anti–epidermal growth factor receptor (EGFR) treatments in patients with KRAS/NRAS wild-type chemorefractory metastatic colorectal cancer. The trial included 47 patients enrolled from November 2012 – December 2016. Patients had tumor biopsies at regular time points at baseline, disease progression, and at partial response in some patients. Patients also provided plasma samples every 4 weeks until disease progression.

Analysis of baseline cfDNA showed that 50% of patients with tumors defined as RAS wild-type based on tissue analysis that harbored aberrations in the RAS pathway in pretreatment cfDNA. These aberrations could explain why patients were resistant to the EGFR inhibitor cetuximab. Patients with aberrations in the RAS pathways were associated with worse progression free (hazard ratio [HR] = 3.41) and overall survival (HR = 2.78) compared with wild-type disease.

Valeri and colleagues developed models that used both cfDNA and carcinoembryonic antigen levels from plasma to predict time to progression. They validated their findings using RECIST measurements taken from radiological imaging data. This model was applied to 6 patients to predict time to clinical progression; of the predictions, 3 were within 10% of progression time as measured by RECIST.

“Integration of novel monitoring technologies like cfDNA, in combination with mathematical modeling of tumor forecasting, may offer the opportunity to act early, stop therapy, or change treatment to stay one step ahead of the disease,” Valeri said in a press release. “Our method allows for a more accurate prediction as well as improved monitoring of response to therapy.”

The researchers acknowledged several limitations to the study including its small size and its focus solely on the RAS pathways. The ability of the model to predict time to progression will need to be validated in other prospective clinical trials, the researchers wrote.
cancer  genomics  modeling 
10 days ago by cnk
Twitter
the merkle dag part of ipfs is sort of like git but there's no diffing and no metadata. I think it's mo…
from twitter
10 days ago by bobpoekert
Twitter
A) he’s an alien from another world, his skin color can be whatever. make him literally orca colored who cares.

B)…
from twitter_favs
10 days ago by ree
Twitter
A) he’s an alien from another world, his skin color can be whatever. make him literally orca colored who cares.

B)…
from twitter_favs
10 days ago by silentbicycle
Twitter
A) he’s an alien from another world, his skin color can be whatever. make him literally orca colored who cares.

B)…
from twitter_favs
10 days ago by evanwalsh
[Update: 512GB variant] iPhone XS, iPhone XS Max and iPhone XR names confirmed in Apple Products Sitemap
Who even cares about a sitemap anymore (search engines maybe?) — and why in the world would Apple’s process for publishing this file include even a chance that it would go live before the event?

ATH only notes the iPhone names, but The Verge noticed that updated Apple Watch bands are in new sizes, 40 and 44 mm, which suggests they’re not compatible with existing Apple Watches.

 ★ 
via:daringfireball 
10 days ago by rufous
Twitter
On June 20, 2016 was

1) Eleven days after the Trump Tower meeting arranged by the Agalorovs

2) The day Paul Mana…
from twitter_favs
10 days ago by andriak
[Update: 512GB variant] iPhone XS, iPhone XS Max and iPhone XR names confirmed in Apple Products Sitemap
from Daring Fireball

Who even cares about a sitemap anymore (search engines maybe?) — and why in the world would Apple’s process for publishing this file include even a chance that it would go live before the event?

ATH only notes the iPhone names, but The Verge noticed that updated Apple Watch bands are in new sizes, 40 and 44 mm, which suggests they’re not compatible with existing Apple Watches.

 ★ 
ifttt  daringfireball 
10 days ago by josephschmitt
(500) https://3weekdiets.mitzuka.com/the-whole30-the-30-day-guide-to-total-health-and-food-freedom/
The Whole30: The 30-Day Guide to Total Health and Food Freedom The Whole30: The 30-Day Guid…
from twitter
10 days ago by jock312
Twitter
The Whole30: The 30-Day Guide to Total Health and Food Freedom The Whole30: The 30-Day Guid…
from twitter
10 days ago by jock312
Twitter
RT : Een klassiek voorbeeld hoe bedrijven van buitenaf onze politiek kunnen beïnvloeden. Ook laat dit zien hoe belangrij…
from twitter
10 days ago by Dymphie
Twitter
Those communities on the front lines of everyday pollution will be forced to contend with a wave of bacteria, heavy…
from twitter_favs
10 days ago by fototropik
Going Fast and Cheap: How We Made Anna Autoscale - RISE Lab
In this post, we describe how we extended the fastest KVS in the cloud to be extremely cost-efficient and highly adaptive.
AnnaKV  database  kvs 
10 days ago by 3goliad
Twitter
やっと、勝った~!!!

久々の #勝利のグラビア 😂!!!!
マジック……7!!!!
from twitter_favs
10 days ago by carios
Twitter
Fantastic to see Unity adopting the modern .NET ecosystem!
from twitter_favs
10 days ago by abolibibelot
REV Group Specialty Vehicle Manufacturers – Fire, RV & Ambulance Vehicle Brands
not really content marketing, but uses elements of content marketing to advertise products. Interesting.
journalism 
10 days ago by msscha
Twitter
RT : Running a Web App or Function App from a package provides a number of key benefits: deployment atomicity, runtime c…
from twitter
10 days ago by paulbatum
Twitter
Going to be in San Francisco on October 6-7?
You should come to the Roguelike Celebration! We have an amazing lineu…
from twitter_favs
10 days ago by douglaswth
Twitter
That's some vintage cut-off-the-air-supply Microsoft tactics when users try to install Firefox or Chrome. While one…
from twitter_favs
10 days ago by dentarg
Twitter
That's some vintage cut-off-the-air-supply Microsoft tactics when users try to install Firefox or Chrome. While one…
from twitter_favs
10 days ago by taurean
Twitter
if youre still having issues i can send you an invite.....DM me your email address if the link doesn…
from twitter
10 days ago by rcsmedia
Twitter
Really useful article from on the relationship between transit use and saving peoples' lives. Roadway…
from twitter_favs
10 days ago by andriak
The Recovery Threw the Middle-Class Dream Under a Benz
Once a year or so, the economist Diane Swonk ventures into the basement of her 1891 Victorian house outside Chicago and opens a plastic box containing the items…
from instapaper
10 days ago by brendanodonnell
Twitter
Because it was an epic example of thievery and misogyny and should be exam…
from twitter_favs
10 days ago by blueroot
Twitter
For folks in and Buncombe County, text BCAlert to 888777 to sign up for emergency alerts about…
Asheville  from twitter_favs
10 days ago by andriak
Twitter
RT : it's bi visibility month so here's an essay i wrote about bisexuality, plus Shakespeare's sonnets and there's also…
from twitter_favs
10 days ago by jtth
« earlier      later »

Copy this bookmark:



description:


tags:



Copy this bookmark:



description:


tags: