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(429) https://twitter.com/i/web/status/1007013348339265536
Twitter numbers have never been important to me but trends are relevant. And the biggest trend I…
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10 days ago by topgold
Twitter
Senate Bill 335 was passed this morning by the Senate. It will allow the Durham-Chapel Hill Light Rail Project to p…
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10 days ago by rossgrady
Immune recognition of somatic mutations leading to complete durable regression in metastatic breast cancer | Nature Medicine
> In total, 11 TCR clonotypes recognized the four neoantigens
(SLC3A2, KIAA0368, CADPS2 and CTSB) for patient 4136. Only
two TCRs, both of which recognized mutSLC3A2 (TRBV7-9–
TRAV26-2 (TCR D) and TRBV19–TRAV9-2 (TCR H)) were detectable
in peripheral blood prior to treatment (0.003% and 0.002% of
all TRBV sequences, respectively). Following the cell infusion, we
evaluated the in vivo persistence of known neoantigen-reactive
TCRs in the peripheral blood. The median cumulative frequency
during weeks 3–12 was 2.83% of the peripheral repertoire, and the
known reactive clonotypes comprised 0.81% of the post-infusion
repertoire at 17 months after infusion (Fig. 4a). Eight of the 11 neoantigen-reactive
TCRs persisted in the patient’s peripheral blood at
least 17 months after treatment (Fig. 4b). In addition, the dominant
clonotypes that were identified 6 weeks after transfer persisted.
To better understand the heterogeneity of the nonsynonymous
mutations within the patient’s tumor, a clonality analysis was performed
on the resected tumor DNA. This analysis revealed that
20/62 (32%) mutations were clonal, 37/62 (60%) were subclonal,
and 5 (8%) mutations could not be determined. MutSLC3A2 and
mutCADPS2 were clonal (cancer cell fraction (CCF): 0.999, each),
whereas, mutCTSB and mutKIAA0368 seemed to be subclonal
(CCF: 0.669 and 0.489, respectively) (Fig. 4c).
car_t  immunotherapy  cancer  2018 
10 days ago by porejide
Twitter
My server at La Fonda keeps calling me ma’am
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10 days ago by jpreyer
Twitter
Antarctic ice melting faster than ever, studies show. This rate of sea level ri…
climate  climatechange  cryosphere  from twitter
10 days ago by cc2050
Twitter
It’s no secret that we are LGBTQIA affirming. If you are a progressive christian (or whatever) and aren’t sure how…
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10 days ago by brchastain
Twitter
didnt trump already meet with kim like last week or something tho
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10 days ago by rjeli
Twitter
Between these two outfits I wore in the sun this weekend, I have a stort of hilarious tan line situation right now.
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10 days ago by quicksilvre
Twitter
RT : Cool that our new mayor is someone who once blocked me on Twitter for supporting the safety of cyclists, who has re…
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10 days ago by edenman
Twitter
we need to create space for all SEA PEOPLE! Ask yourself, clothmo: am I taking up space which could be…
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10 days ago by rjeli
Twitter
it is good day to be good dog
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10 days ago by ruthherself
Ivanti récompense ses partenaires EMEA - ChannelNews
Ivanti récompense ses partenaires EMEA

Ivanti récompense ses partenaires EMEA  Channelnews

Ivanti récompense ses partenaires européens  Global Security MagFull coverage

https://ift.tt/2y4MJAB
MarketIntelligence 
10 days ago by SergioWerner
Twitter
RT : ABSTRACT ART WITH ML. Excited to say that today I'm launching my ML blog. First post is up and more will be coming…
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10 days ago by todbot
Twitter
Me: I don't know why I'm so clumsy lately. The other day I nearly slipped and fell in the kitchen.

Donna: [concern…
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10 days ago by donnadb
Twitter
You can then probably make the symbol a block with width 100% (probably with absolute positioning) and do a te…
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10 days ago by garrett
Twitter
Can we get these on Figueroa's new bike lanes because cars are parking in them despite painted parking hatches...
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10 days ago by azadag
Twitter
I think Iceland is a one-week destination: 3 or 4 days driving around, a day doing the circle tour, a…
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10 days ago by peterhoneyman
Time in a Bottle - astolat - Stargate Atlantis [Archive of Our Own]
Summary:

To see a World in a Grain of Sand / And a Heaven in a Wild Flower / Hold Infinity in the palm of your hand / And Eternity in an hour.
f:sga  virtual.reality  stasis  p:rodney/john 
10 days ago by miss_speller
Building Serverless Mobile Applications with React Native & AWS
In this post, we’ll look at how to build fully serverless & backendless mobile applications with AWS Amplify & React Native that include features like…
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10 days ago by kevinold
Twitter
I have died. (via 's newsletter: , which I would highly recommend were I not dead.)
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10 days ago by jtth
Today in Librarian Tabs by Jessamyn West
I have died. (via 's newsletter: , which I would highly recommend were I not dead.)
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10 days ago by jtth
Twitter
Some folks are arguing for precisely this
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10 days ago by kcarruthers
Twitter
You're drained after work. All you want to do is relax on the couch. On weekends, you want to spend time with frien…
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10 days ago by brittanmcg
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