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I’m so grateful to CJR for working with me on this story, and particularly to Managing Editor Betsy Morais—who trul…
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10 days ago by andriak
Online Learning HUB – TU Delft online learning community
The goal of the Online Learning HUB is to support and facilitate TU Delft faculty to teach and develop online courses with teachers as active and reflective participants. However, the HUB is useful for everyone involved in online course development. TU Delft lecturers who are interested in creating a new online course can apply for support via a tender procedure.
elearning  facultyservice  dlorg 
10 days ago by oheredia
Melanoma-Derived Soluble DC-HIL/GPNMB Promotes Metastasis by Excluding T-Lymphocytes from the Pre-Metastatic Niches - ScienceDirect
Interesting that these are high heparansulphate sites - so perhaps DC-HIL is marking high HS containing ES cells, which enable more effective extravasation and inhibition of T cells (for some reason....). Another paper in cancer research says GPNMB I think also goes up with tumor cell stemness/dormancy.

"In summary, melanoma exploits the DC-HIL pathway to increase the success rate of metastasis by secreting sDC-HIL, which binds to the DHL+ EC vascular niches. This binding awakens the angiogenic potential and excludes T cells from the niches while enhancing the migration of BMPs and tumor cells. Therefore, sDC-HIL is an endothelial gatekeeper for selectively blocking the access of T cells to the vascular niches. In this context, blocking sDC-HIL function may be a promising approach for preventing metastasis of melanoma because we showed that infusion of anti-DC-HIL mAb markedly regressed metastases. This possibility is not restricted to melanoma because we showed that some of patients with metastatic forms of other malignancies also produce very high levels of sDC-HIL in the blood (unpublished data).
extravasation  lung_colonization  endothelium  heparan_sulfate  immune_suppression 
10 days ago by Segalllab
Remove Background from Image – remove.bg
useful utility for removing image backgrounds
background  image  images 
10 days ago by dgibbons
(429) https://twitter.com/i/web/status/1083071865734811648
a) they're called 'readers' and b) people are upset because they hold the New York Times to a high…
from twitter_favs
10 days ago by maura
Grow As A Design Manager
You’re passionate about building teams and helping people realize their full potential. However, the waters of design management can be pretty choppy. Here are ways to approach these challenges!
playbook  management  tools  leadership  design 
10 days ago by mayshek
What to Do If Users Mistap Your Icon Buttons
If you’ve designed a mobile app before, you know how useful and prevalent icon buttons are. But what you don’t know is how often users mistap them when they’re placed too close together.
ux  ux--patterns  wd  wd-forms  wd-forms--button  wd-input--touch 
10 days ago by ericwbailey
Twitter
RT : Acabo de descubrir que la peli original de Perfectos Desconocidos es italiana (yo pensaba que era francesa) y que a…
from twitter
10 days ago by deckard67
Dump LAPS password in clear text – Akijosberry
By Default all the Domain Admins have view access to ms-MCS-AdmPwd attribute. Lets have a look at the following ways in which we can dump the LAPS password
account  ad  directory  pentest  postexploitation 
10 days ago by whip_lash
Twitter
Camélia Jordana en musique du monde ? 🤔
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10 days ago by bperrier
Twitter
When Sine Die is upon Texas, there's the constant lament of things that didn't get done in the Session. Maybe it's…
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10 days ago by quicksilvre
Twitter
my climate change theory, from
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10 days ago by evanwalsh
(429) https://twitter.com/i/web/status/1083071737506480128
Solution: A Continuing Resolution that includes a declaration that POTUS is the smartest, fastest, most handsome b…
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10 days ago by artlung
Twitter
JUST IN: FDA says routine food inspections stopped because of shutdown, raising health concerns…
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10 days ago by chetan
Twitter
RT : Ya hemos publicado 10 episodios de nuestro nuevo podcast y seguimos subiendo uno nuevo cada semana, suscríbete (o s…
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10 days ago by deckard67
Twitter
OK, this is cool: there's a class of learnability problems that's equivalent to the continuum hypothesis, and thus…
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10 days ago by etorreborre
(429) https://twitter.com/i/web/status/1083071584607207425
ConsenSys probably held at least half of the equity for each of its startups, including infrastructure, & Lubin rep…
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10 days ago by jakemcgraw
Twitter
RT : I posed as a potential customer to the company selling phone location data for a wide array of businesses. I explic…
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10 days ago by briantrice
Twitter
When I receive a speaking invite, my first q is: could I do a low-carbon video talk? Thanks to peoples' willingness…
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10 days ago by joostvanderborg
Twitter
RT : "The imperial presidency is, in many ways, propped up by media partisans who insist that the naked emperor has glor…
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10 days ago by delong
Twitter
RT : ICYMI: 40 card packs bundle from Wild sets is available for $24.99 (50% discount). Top 100 Wild Legend players from…
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10 days ago by WickedGood
SupChina - China News & Commentary | Sinica Podcast | Daily News App
SupChina is an independent digital media company that informs and entertains a global audience of influencers and leaders with smart, accessible content, helping them make sense of a complex country that is reshaping the world. Featuring a daily newsletter and the Sinica Podcast.
10 days ago by jberkel
Twitter
und warum muß man dazu fliegen?

Grüße von einem Autolosen, der seine Reisen, auch ins e…
from twitter
10 days ago by tmmd
Twitter
Great to meet with the SF based Propeller Health team last night! Together we are going to change millions of live…
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10 days ago by dvansickle
Twitter
An unusually deep, thorough, occasionally personal, review of Enlightenment Now by humanities scholar Geoffrey Harp…
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10 days ago by sprague
Adaptive Information Design and the Box Diagram :: UXmatters
Once your team understands the requirements for an entire project, you can sort the same requirements cards within a single view to understand how best to…
from instapaper
10 days ago by aktaplin
Twitter
RT : I was Googling a phone number and came across this site [phonenumber].phonesear.ch. Each entry has a lengthy "Comme…
from twitter
10 days ago by rossgrady
James Lucas (illustrator) - Wikipedia
I wrote a Wikipedia biography of James Lucas, an illustrator who worked in the 1930s.
tweetit  mywpcreation  biography  art 
10 days ago by pigsonthewing
Twitter
But raise the floor a bit. As a small business owner I pay taxes to city, county, state, and IRS. Plus compliance c…
from twitter_favs
10 days ago by whyitsjeff
Twitter
Bargains galore in Oxfam Penarth
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10 days ago by datz53
Twitter
A bot generated and submitted it as a PR, but now that PR seems to have been delete…
from twitter
10 days ago by mahmoud
Nyheder om forskning og videnskab
Skrev den anden dag, at man mødes med vrede, når man forsker i ⁠. Min artikel i blev…
metoo  from twitter_favs
10 days ago by mikkelmarius
Twitter
Skrev den anden dag, at man mødes med vrede, når man forsker i ⁠. Min artikel i blev…
metoo  from twitter_favs
10 days ago by mikkelmarius
Twitter
@DesignerDepot : "We are busy being busy. Busy preparing the A and the B variations to test, busy setting up remote testing sessions, busy updating the prototype URL in the Trello card". https://t.co/DoLShqn6Gq : http://twitter.com/DesignerDepot/status/1083070919302631426
design  layout  graphic  web-design  web-dev  css  css3  webdev  html 
10 days ago by dcolanduno
Twitter
can’t wait to set my github away status to song lyrics that are also a low-key message to my secret crush
from twitter_favs
10 days ago by brittanyforks
Twitter
RT : User research myth : "We can set up a diary study and leave it running"
Anything involving participants needs man…
from twitter
10 days ago by arvindv
(429) https://twitter.com/i/web/status/1083071192372670464
Not sure I understand the q about context, but actionable things:

Me-scale: somatic therapies, enou…
from twitter_favs
10 days ago by brozena
Favorite by @alanfeuer
A jaw-dropping twist this morning to the story of the Colombian IT guy who helped the FBI crack El Chapo's encrypted comms network.
He also helped the feds tap…
from instapaper
10 days ago by mathewi
Twitter
Brian Schatz (@brianschatz)
RT @JanieVelencia: Polls this week all show an increasing number of Americans are blaming Trump over Dems for the shutdown. https://t.co/…
US  Senators  Twitter 
10 days ago by AlexanderERyzhov
Twitter
SAD!

"Unfortunately for them, Trump and his retinue didn’t pay close attention to Snowden’s revelations about the…
from twitter_favs
10 days ago by johnattebury
Twitter
Senator John Thune (@SenJohnThune)
RT @argusleader: The agreement would allow Verizon to attach the cell towers to existing light poles, buildings and water towers. https://t…
US  Senators  Twitter 
10 days ago by AlexanderERyzhov
Twitter
Senator John Thune (@SenJohnThune)
RT @keloland: The City of Sioux Falls officially partnered with Verizon Wireless to install the technology needed to make 5G a reality thro…
US  Senators  Twitter 
10 days ago by AlexanderERyzhov
Twitter
Senator John Thune (@SenJohnThune)
I've fought for years to lay the groundwork to bring the world's fastest internet to South Dakota, and with last night's city council vote, Sioux Falls is officially ready to make 5G internet a reality. Thanks to @paultenhaken for encouraging 5G development in the state.
US  Senators  Twitter 
10 days ago by AlexanderERyzhov
TREE :Manchester International Festival
"James Ngcobo at the Market Theatre Johannesburg." - TREE http://bit.ly/2FjIByF
quote 
10 days ago by Geemarc
Twitter
When and pathologize traditional masculinity, I wonder how many men with traditional values did the…
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10 days ago by SWCarson
Twitter
my guy took a picture of himself from getty images and left the watermark on it. insanely alpha move
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10 days ago by matthewog
Twitter
I am so happy to be in one of my favorite cities and perform Schumann’s Concert for piano in A minor with my dear f…
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10 days ago by jordanrssmith
Fun Birthday Traditions That Everyone Loves - The Toast - The Toast
Accept the blindfold. Accept the bat. Accept the darkness all around you. from
from twitter
10 days ago by skybondsor
Twitter
*checks notes* his family moved to Qatar due to death threats
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10 days ago by drunkengrass
Twitter
Senator, as a constituent I am very disappointed by this tweet. You voted for CRs without wall fund…
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10 days ago by coty
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